Faculty

Soojung Claire Hur

Clare Boothe Luce Assistant Professor

Research Interests

Inertial microfluidics, nonlinear fluid dynamics, multiphase flow, cellular biophysics, cell mechanics, single cell manipulations, personalized medicine, regenerative medicine.

Soojung Claire Hur, the Clare Boothe Luce Assistant Professor in the Department of Mechanical Engineering, is an expert in microfluidics. She is a fellow of the Hopkins Extreme Materials Institute, an associate researcher at the Johns Hopkins Institute for NanoBioTechnology, and holds a secondary appointment in the Department of Oncology at the Johns Hopkins University School of Medicine.

Through the Hur Lab on Micro-Fluidic Biophysics, Hur is working to develop microfluidic platforms to understand complex fluid dynamics principles and to translate acquired knowledge into practical applications. In particular, she is interested in studying single-cell mechanics and understanding the veiled correlations between cellular functions and their physical phenotypes. Her lab utilizes a unique microscale hydrodynamic phenomenon called inertial focusing to accomplish high-throughput target cell detection, cost-effective cell separation, and sequential multimolecular delivery. They aim to create innovative techniques for use in high-throughput target cell detection, cost-effective cell separation, and sequential multimolecular delivery that are useful for oncology, immunology, gene therapy, tissue engineering and regenerative medicine. Hur holds three U.S. patents and two international patents for her work.

Hur is a member of several professional scientific societies including the American Association for Cancer Research (AACR), the American Society of Mechanical Engineers (ASME) and the American Chemical Society (ACS). She serves as an editor for the journals Nature Scientific Reports, SLAS Technology special issue, and Biomicrofluidics: Microfluidics, Circulating Biomarkers and Cancer. She also is a reviewer for additional science journals, such as PLoS One and the Annals of Biomedical Engineering; agencies such as the National Science Foundation (NSF) and National Aeronautics and Space Administration (NASA); and conferences for organizations, such as ASME.

She has won numerous awards and scholarships, including the Edward K. Rice Outstanding Doctoral Student award, the HSSEAS (UCLA Henry Samueli School of Engineering and Applied Science) academic scholarship, the UCLA Mechanical and Aerospace Engineering Department’s Chevron scholarship and UCLA Dean’s special fellowship, the 2018 inaugural Johnson and Johnson WiSTEM2D Scholars Award, and the School of Engineering Junior Faculty Award at the 2018 Johns Hopkins Department of Medicine Research Retreat.

Hur received her bachelor’s degree, master’s and doctoral degrees in mechanical engineering from the University of California, Los Angeles, in 2005, 2007 and 2011, respectively. In September 2011, with five years of research funding, she joined the Rowland Institute at Harvard University as one of two Rowland Fellows . Next, Hur managed clinical studies funded by Vortex Biosciences, Inc. as an assistant researcher at UCLA Department of Bioengineering. She joined the Whiting School of Engineering faculty in 2015.

 

 

Education
  • Ph.D. 2011, Univ of California Los Angeles
  • Master of Science 2007, Univ of California Los Angeles
  • Bachelor of Science 2005, Univ of California Los Angeles
Experience
  • 2018 - Present:  Joint, SOM Oncology Center
  • 2016 - 2017:  Assistant Researcher, UCLA
  • 2015 - 2016:  Project Leader, Vortex Biosciences, Inc.
  • 2011 - 2015:  Rowland Fellow, Harvard University
  • 2011 - 2011:  Postdoctoral scholar, UCLA
Research Areas
  • BIOMEDICAL engineering -- Instruments
  • Cancer research -- United States
  • Microfluidics methods
  • Nonlinear fluid mechanics
  • PANCREATIC cancer -- Diagnosis
Awards
  • 2018:  Johnson and Johnson WiSTEM2D Scholar
  • 2018:  Whiting School of Engineering Junior Faculty Award
  • 2017:  Clare Boothe Luce Assistant Professorship
  • 2013:  Rising Stars in EECS
  • 2011:  Rowland Junior Fellowship
  • 2011:  Edward K. Rice Outstanding Doctoral Student Award
  • 2010:  14th MicroTAS travel grant
  • 2010:  Academic Travel Grant
  • 2010:  NSF ADVANCE Distinguished post-doctoral and doctoral student speaker series
  • 2010:  Tony B. Award
  • 2007:  Travel grant for the 5th international Symposium on Radiative Transfer
  • 2005:  Dean's Special Graduate Fellowship
  • 2005:  Scholarship
  • 2004:  Henry Samueli School of Engineering and Applied Science Academic Scholarship
  • 2004:  MAE Department Chevron Scholarship
  • 2003:  Tau Beta Pi
  • 2003:  Dean's list
Journal Articles
  • Ouyang M, Lee JH, Hill W, Hur SC (2017).  Microscale Symmetrical Electroporator Array as a Versatile Molecular Delivery System.  Scientific Reports.  7.  44757.
  • Vickers DAL, Ouyang M, Choi CH, Hur SC (2014).  Direct Drug Cocktail Analyses using Microscale Vortex-assisted Electroporation.  Analytical Chemistry.
  • Vickers DAL, Hur SC (2014).  Microscale Vortex-assisted Electroporator for Sequential Molecular Delivery.  Journal of Visualized Experiments.
  • Yun H, Hur SC (2013).  Sequential Multi-molecule Delivery using Vortex-assisted Electroporation.  Lab on a chip.
  • Hur SC, Brinkerhoff TZ, Walthers CM, Dunn JCY, Di Carlo D (2012).  Label-free Enrichment of Adrenal Cortical Progenitor Cells using Inertial Microfluidics.  PLoS One.
  • Goda K, Ayazi A, Gossett DR, Sadasivam J, Lonappan CK, Sollier E, Fard AM, Hur SC, Adam J, Murray C, Wang C, Brackbill N, Di Carlo D, Jalali B (2012).  High-throughput Single-microparticle Imaging Flow Analyzer.  PNAS.
  • Hur SC, Choi SE, Kwon S, Di Carlo D (2011).  Inertial Focusing of Non-spherical Particles.  Applied Physics Letters.
  • Mach AJ, Kim J, Arshi A, Hur SC, Di Carlo D (2011).  Automation of Cellular Sample Preparation using a Centrifuge-on-a-chip.  Lab on a chip.
  • Hur SC, Mach AJ, Di Carlo D (2011).  High-throughput Size Based Rare Cell Enrichment using Microscale Vortices.  Biomicrofluidics.
  • Chun YJ, Hur SC, Kealey C, Levi DS, Di Carlo D, Mohanchandra KP, Vinuela F, Carman GP (2011).  A Novel Neurovascular Stent Covered in Stretchable Thin Film NiTi Significantly Decreases Flow into a Wide-Neck Aneurysm In Vitro.  Smart materials and structures.
  • Hur SC, Handerson-MacLennan NK, McCabe ERB, Di Carlo D (2011).  Deformability-based Cell Classification and Enrichment using Inertial Microfluidics.  Lab on a chip.
  • Kealey CP, Whelan SA, Chun YJ, Hur SC, Tulloch AW, Mohanchandra KP, Di Carlo D, Levi DS, Carman GP, Rigberg DA (2010).  In vitro Hemocompatibility of Thin Film Nitinol in Stenotic Flow Conditions.  Biomaterials.
  • Gossett DR, Weaver WM, Mach AJ, Hur SC, Tse HTK, Lee W, Amini H, Di Carlo D (2010).  Label-free Cell Separation and Sorting in Microfluidic Systems.  Analytical and Bioanalytical Chemistry.
  • Hur SC, Tse HTK, Di Carlo D (2009).  Sheathless Inertial Cell Ordering for Extreme Throughput Flow Cytometry.  Lab on a chip.
Book Chapters
  • Hur SC (2017).  Microscale Laminar Vortices for High-Purity Extraction and Release of Circulating Tumor Cells.  Circulating Tumor Cells.  Humana Press.
  • Chung AJ, Hur SC (2015).  High-Speed Microfluidic Manipulation of Cells.  Micro- and Nanomanipulation Tools.  Wiley-VCH.
Conference Proceedings
  • Ouyang Mengxing, Choi Chris H., Lee Jung Hyun, Hill Winfield, Hur SC (2017).  Invited: Microfluidic Vortex-Assisted Electroporation integrated with Label-free Cell Purification.  10th International Conference on Advanced Materials and Devices.
  • Ouyang Mengxing, Choi Chris H, Lee Jung Hyun, Hill Winfield, Hur SC (2017).  Invited: Vortex-assisted Electroporation integrated with label-free cell purification.  IEEE NEMS 2017.
  • Ouyang Mengxing, Choi Chris H, Lee Jung Hyun, Hill Winfield, Hur SC (2017).  Invited: Microfluidic Electroporator for Multimolecular Delivery into Purified Target Cells.  2nd World Congress on Electroporation and Pulsed Electric Fields in Biology, Med.
  • Ouyang Mengxing, Choi Chris H., Lee Jung Hyun, Hill Winfield, Hur SC (2016).  Vortex-assisted Electroporation toward Personalized Medicine.  GRC 2016: Rare Cells in Circulation.
  • Ouyang Mengxing, Choi Chris H., Lee Jung Hyun, Hill Winfield, Hur SC (2016).  Integrated Microfluidic Electroporator for Multimolecular Delivery into Purified Target Cells.  SLAS 2016.
  • Ouyang Mengxing, Lee Jung Hyun, Hill Winfield, Hur SC (2015).  Invited: A Versatile Microfluidic Electroporator for Medicine and Biological Research.  IEEE-Nanomed 2015.
  • Ouyang Mengxing, Lee Jung Hyun, Hill Winfield, Hur SC (2015).  Miniaturized Electroporator Array as a Versatile Molecular Delivery System.  µTAS 2015.
  • Choi Chris H., Ouyang Mengxing, Hur SC (2015).  Multimolecule Electroporation Mediated Delivery Integrated on Chip (MEDiC) for Cancer Cells Purified from a Whole Blood.  microTAS 2015.
  • Ouyang Mengxing, Lee Jung Hyun, Hill Winfield, Hur SC (2015).  A Versatile Microfluidic Molecular Delivery System based on Electroporator Array.  BMES 2015.
  • Choi Chris H., Ouyang Mengxing, Hur SC (2015).  Multimolecule Electroporation Mediated Delivery Integrated on Chip (MEDiC) towards Personalized Medicine.  BMES 2015.
  • Ouyang Mengxing, Lee Jung Hyun, Hill Winfield, Hur SC (2015).  A Versatile Microfluidic Electroporator for Medicine and Biological Research.  World Congress on Electroporation 2015.
  • Ouyang Mengxing, Choi Chris H., Lee Jung Hyun, Hill Winfield, Hur SC (2015).  Vortex-assisted Electroporation toward Personalized and Regenerative Medicine.  GRC 2015: Microfluidics, Physics and Chemistry of.
  • Vickers Dwayne A. L., Hur SC (2014).  Drug Cocktail Screening towards Combination Therapy.  µTAS 2014.
  • Vickers Dwayne A. L., Hur SC (2014).  Vortex-assisted Electroporation for Combinatorial Drug Screenings.  BMES 2014.
  • Hur SC (2013).  Identification of Viscous Droplets’ Physical Properties that Determine Droplet Behaviors in Inertial Microfluidics.  66th Annual APS Division of Fluid Dynamics.
  • Hur SC (2013).  Behavior Determining Factors for Droplets in Inertial Flow.  GRC 2013: Microfluidics, Physics and Chemistry of.
  • Yun Hoyoung, Hur SC (2012).  Microfluidic Vortex-assisted Sequential Electroporation.  IEEE MNMC 2012.
  • Yun Hoyoung, Hur SC (2012).  µTAS 2012.  On-chip Sequential Molecular Delivery into Isolated Cells by Vortex Assisted Ele.
  • Yun Hoyoung, Hur SC (2012).  A Single-cell Level Microfluidic Electroporation for Sequential Molecule Delivery.  BMES 2012.
  • Masaeli Mahdokht, Sollier Elodie, Amini Hamed, Hur SC, Doshi Nishit, Mitragotri Samir, Di Carlo Dino (2011).  Effect of Particle Shapes on Inertial Focusing.  BMES 2011.
  • Hur SC, Di Carlo Dino (2011).  Effect of Fluid Inertia on Lateral Migration of Deformable Cells.  GRC 2011: Microfluidics, Physics and Chemistry of.
  • Chun Youngjae, Hur SC, Di Carlo Dino, Carman Greg P. (2011).  A Novel Hyper-elastic Thin Film Nitinol Covered Stent Significantly Decreases Intra-aneurysmal Flow in vitro.  The SPIE Symposium on SPIE Smart Structures and Materials + Nondestructive Evalu.
  • Carman Greg, Chun Y.J., Mohanchandra K.P., Levi Daniel S., Kealey Colin, Hur SC, Di Carlo Dino, Vinuela Fernando (2011).  A Hyper-Elastic Thin Film Nitinol Flow Diverter for Brain Aneurysms.  TMS 2011.
  • Kilimnik Alex, Hur SC, Di Carlo Dino, Alexeev Alexander (2010).  Cross-stream Migration of Compliant Particles in Microfluidic Channels.  63rd Annual Meeting of the APS Division of Fluid Dynamics.
  • Mach Albert J., Kim Jae H., Hur SC, Di Carlo Dino (2010).  Centrifuge-on-a-chip: Selective Cell Trapping with Rapid Solution Exchange in Microvortices.  µTAS 2010.
  • Hur SC, Mach Albert J., Di Carlo Dino (2010).  High-throughput Size based Rare Cell Isolation using Microscale Vortices.  µTAS 2009.
  • Hur SC, Di Carlo Dino (2010).  Passive Label-free Rare Cell Enrichment Inertial Microfluidic Device using Cell Deformability as a Biomarker.  µTAS 2010.
  • Chun Youngiae, Levi Daniel S., Hur SC, Kealey Colin, Tulloch Allan W., Mohanchandra KP, Rigberg David A., Di Carlo Dino, Lawrence Peter F., Vinuela Fernando, Vinuela Fernando Jr., Carman Gregory P. (2010).  Thin Film Nitinol Vascular Grafts for Treating Intracranial Aneurysms.  UKC 2010.
  • Hur SC, Di Carlo Dino (2010).  High Throughput Deformability Measurement and Deformability Activated Cell Enrichment using Inertial Microfluidics.  UKC 2010.
  • Wu Ting-Hsiang, Chen Yue, Park Sung-Young, Hur SC, Di Carlo Dino, Chiou Eric P. (2010).  Pulsed Laser Triggered High Speed Fluorescence Activated Microfluidic Switch.  Optical MEMS and Nanophotonics 2010.
  • Hur SC, Di Carlo Dino (2010).  High Frequency Deformability Activated Cell Enrichment using Inertial Microfluidics.  The 16th US National Congress of Theoretical and Applied Mechanics.
  • Chun Youngiae, Hur SC, Kealey Colin, Tulloch Allan W., Levi Daniel S., Di Carlo Dino, Chang Hsin-Yun, Mohanchandra K.P., Rigberg David A., Lawrence Peter F., Carman Gregory P. (2010).  A Novel Neurovascular Stent Covered in Stretchable Thin Film NiTi Significantly Decreases Flow into a Wide-neck Aneurysm in vitro.  American Society for Artificial Internal Organs (ASAIO).
  • Hur SC, Tse Henry T. K., Di Carlo Dino (2010).  Massively Parallel Inertial Ordering for High-throughput Sheathless Imaging Flow Cytometry.  Lab Automation 2010.
  • Chun Youngiae, Levi Daniel S., Tulloch Allan W., Hur SC, Kealey Colin, Mohanchandra KP, Rigberg David A., Lawrence Peter, Vinuela Fernando Jr., Carman Gregory P. (2010).  Hemocompatible Thin Film Stent-grafts for Treating Neurovascular Diseases.  The 6th Annual Young Generation Technical & Leadership Conference.
  • Hur SC, Di Carlo Dino (2010).  Towards High-throughput Deformability Activated Cell Sorting (DACS) using a Microfluidic System.  The 6th Annual Young Generation Technical & Leadership Conference.
  • Hur SC, Di Carlo Dino (2009).  Evaluation of High-throughput Cell Sorting based on Deformability in a Microfluidic System.  µTAS 2009.
  • Hur SC, Di Carlo Dino (2009).  Feasibility Study of a Deformability-Activated Cell Sorting Microfluidic Platform.  The Society of Rheology 81st Annual Meeting.
  • Hur SC, Di Carlo Dino (2009).  Evaluation of High-throughput Cell Sorting based on Deformability in a Microfluidic System.  BMES 2009.
  • Hur SC, Di Carlo Dino (2009).  Evaluation of High-throughput Cell Sorting based on Deformability in a Microfluidic System.  GRC 2009: Microfluidics, Physics and Chemistry of.
  • Hur SC, Di Carlo Dino (2009).  Cancer Cell Isolation using Inertial Microfluidics.  UCLA Engineering Tech Forum 2009.
  • Hur SC, Pilon Laurent, Christensen Adam, Graham Samuel (2007).  Thermal Conductivity of Cubic Mesoporous Silica Thin Films.  ASME 2007 International Mechanical Engineering Congress and Exposition.
  • Hur SC, Pilon Laurent (2007).  Optical Properties of Cubic Mesoporous Silica Thin Films.  Fifth International Symposium on Radiative Transfer.
  • Hur SC, Pilon Laurent (2007).  Synthesis and Characterization of Mesoporous Silica Thin Films.  The 1st Nagoya University –UCLA international Symposium.
  • Hur SC, Pilon Laurent (2007).  Synthesis and Characterization of Nanoporous Thin-films.  KAIST_UCLA Student Workshop.
Patents
  • Hur SC  "Circulating Tumor Cell Immortalization via Vortex Electroporation Mediated Gene Delivery", 2016.
  • Hur SC  "System and Method for Modulating Physical Stimuli on Living Cells/organisms to Manipulate Biological Processes", 2016.
  • Hur SC, Mengxing Ouyang  "Electrode Array for the Vortex-Assisted Electroporation", 2016.
  • Hur SC, Dwayne A. L. Vickers  "Drug Cocktail Analyses using Microscale Vortex-Assisted Electroporation", 2015.
  • Hur SC, Hoyoung Yun  "Microfluidic vortex-assisted electroporation system and method", 2013.
  • Dino Di Carlo, Hur SC  "Systems and methods for particle classification and sorting", 2010.
  • Dino Di Carlo, Hur SC, Albert J. Mach  "Method and device for isolating cells from heterogeneous solution using microfluidic trapping vortices", 2010.
  • Dino Di Carlo, Aydogan Ozcan, Bahram Jalali, Hur SC, Henry T. K. Tse  "Inertial particle focusing flow cytometer", 2010.
  • "Differential Inertial Microfluidics for Biomedical Research", Mechanical Engineering Seminar.  Korea (the Republic of).  December 14, 2017
  • "Differential Inertial Microfluidics for Biomedical Research", Mechanical Engineering Seminar.  Korea (the Republic of).  December 13, 2017
  • "Differential Inertial Microfluidics for Biomedical Research", Graduate School of Nanoscience & Technology Seminar.  Korea (the Republic of).  December 12, 2017
  • "Differential Inertial Microfluidics for Biomedical Research", Mechanical Engineering Seminar.  Korea (the Republic of).  December 11, 2017
  • "Inertial microfluidics: Label-free Cell Manipulation for Biomedical Research", Mechanical Engineering Seminar.  May 15, 2015
  • "Differential Inertial Microfluidics: Label-free cell manipulation for biological research".  March 24, 2015
  • "Differential Inertial Microfluidics: Label-free cell manipulation for biological research", Mechanical Engineering Department Seminar.  Baltimore MD.  March 10, 2015
  • "Differential Inertial Microfluidics: Label-free cell manipulation for biological research", Mechanical Engineering Seminar.  February 9, 2015
  • "Vortex generating inertial microfluidics: Target cell purification and therapeutic molecular delivery", 4th annual netScientific Workshop.  Switzerland.  December 13, 2014
  • "Differential Inertial Microfluidics: Label-free cell manipulation for biological research", Biotec Forum.  Dresden, Germany.  December 8, 2014
  • "Differential Inertial Microfluidics: Label-free cell manipulation for biological research".  September 26, 2014
  • "Differential Inertial Microfluidics: Label-free cell manipulation for biological research", Chemical Engineering Seminar.  CA.  September 26, 2014
  • "Differential Inertial Microfluidics: Label-free cell manipulation and functionalization for biomedical research", Biomedical Engineering Seminar.  August 11, 2014
  • "Vortex generating inertial microfluidics: Target cell purification and therapeutic molecular delivery", NSF Workshop on Micro- and Nanotechnologies for Medicine.  July 30, 2014
  • "Differential Inertial Microfluidics: Label-free cell manipulation and functionalization for biomedical research", Center for Fluid Mechanics Seminar.  February 11, 2014
  • "Differential Inertial Microfluidics: Label-free cell manipulation for biological research", Rising Stars in EECS, An Academic Career Workshop for Women.  November 4, 2013
  • "Differential Inertial Microfluidics: Label-free cell manipulation for biomedical research", Topics in Applied Microfluidics (Graduate Course 10.S95).  October 22, 2013
  • "Differential Inertial Microfluidics: Label-free cell manipulation for biological research", NSF Workshop on Micro- and Nanotechnologies for Medicine.  August 1, 2013
  • "Differential Inertial Microfluidics: Deformability-based manipulation of disperse phase", 53rd New England Workshop on Complex Fluids.  November 30, 2012
  • "Differential Inertial Microfluidics: Label-free cell manipulation for biomedical research".  November 6, 2012
  • "Inertial microfluidics: Label-free Cell Manipulation for Biomedical Research", Special Chemical Engineering Seminar.  October 3, 2012
  • "Target cell identification and enrichment using inertial microfluidics", Khademhosseini research group seminar.  February 17, 2012
  • "Target cell identification and enrichment using inertial microfluidics", Squishy Physics & Pizza Seminar Series.  February 5, 2012
  • "High throughput and label-free target cell classification and enrichment using inertial microfluidics", Micro/Nanofluidic BioMEMS group seminar.  December 6, 2011
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