Faculty

Sean Sun

Professor

Research Interests

Mechanobiology of the cell, molecular biomechanics and biophysics, molecular motors and muscle, statistical mechanics and nonlinear phenomena.

Education
  • Ph.D. 1998, University of California Berkeley
  • B.S. 1994, Pennsylvania State University
Research Areas
  • Cell Motility
  • Molecular Motors
  • Proteins and Membranes
  • Statistical Mechanics
  • Theoretical biomechanics and biophysics
Awards
  • 2017:  Fellow
  • 2016:  Fellow
  • 2015:  Johns Hopkins President's Frontier Finalist
  • 2010:  Alexander von Humboldt Fellowship
  • 2009:  Johns Hopkins University Faculty Scholar
  • 2006:  National Science Foundation CAREER Award
  • 1992:  Eberly College of Science Scholar - Pennsylvania State University
  • 1990:  University Scholar - Pennsylvania State University
Journal Articles
  • Stroka, K. M., Gu, Z., Sun, S., Konstantopoulos, K. (2014).  Bioengineering paradigms for cell migration in confined microenvironments.  Current Opinion in Cell Biology.  30.  41-50.
  • Stroka, K. M., Gu, Z., Sun, S., Konstantopoulos, K. (2014).  Bioengineering paradigms for cell migration in confined microenvironments.  Curr Opin Cell Biol.  30.  41-50.
  • Li, B., Sun, S. (2014).  Coherent Motions in Confluent Cell Monolayer Sheets.  Biophysical Journal.  107(7).  1532-1541.
  • Sun, S. (2014).  How Accurately Can a Single Receptor Measure Ligand Concentrations?.  Biophysical Journal.  106(4).  778-779.
  • Koride, S., He, L., Xiong, L., Lan, G., Montell, D. J., Sun, S. (2014).  Mechanochemical regulation of oscillatory follicle cell dynamics in the developing Drosophila egg chamber.  Molecular Biology of the Cell.  25(22).  3709-3716.
  • Powers, R. J., Kulason, S., Atilgan, E., Brownell, W. E., Sun, S., Barr-Gillespie, P. G., Spector, A. (2014).  The Local Forces Acting on the Mechanotransduction Channel in Hair Cell Stereocilia.  Biophysical Journal.  106(11).  2519-2528.
  • Wu, P., Giri, A., Sun, S., Wirtz, D. (2014).  Three-dimensional cell migration does not follow a random walk.  Proceedings of the National Academy of Sciences of the United States of America.  111(11).  3949-3954.
  • Stroka, K. M., Jiang, H., Chen, S., Tong, Z., Wirtz, D., Sun, S., Konstantopoulos, K. (2014).  Water permeation drives tumor cell migration in confined microenvironments.  Cell.  157(3).  611-23.
  • Stroka, K. M., Jiang, H., Chen, S., Tong, Z., Wirtz, D., Sun, S., Konstantopoulos, K. (2014).  Water Permeation Drives Tumor Cell Migration in Confined Microenvironments.  Cell.  157(3).  611-623.
  • Stukalin, E. B., Aifuwa, I., Kim, J., Wirtz, D., Sun, S. (2013).  Age-dependent stochastic models for understanding population fluctuations in continuously cultured cells.  Journal of the Royal Society Interface.  10(85).
  • Jiang, H., Sun, S. (2013).  Cellular Pressure and Volume Regulation and Implications for Cell Mechanics.  Biophysical Journal.  105(3).  609-619.
  • Chen, W., Wu, P., Phillip, J. M., Khatau, S. B., Choi, J. M., Dallas, M. R., Konstantopoulos, K., Sun, S., Lee, J. S., Hodzic, D., Wirtz, D. (2013).  Functional interplay between the cell cycle and cell phenotypes.  Integrative Biology.  5(3).  523-534.
  • Chen, W., Wu, P. H., Phillip, J. M., Khatau, S. B., Choi, J., Dallas, M. R., Konstantopoulos, K., Sun, S., Lee, J. S., Hodzic, D., Wirtz, D. (2013).  Functional interplay between the cell cycle and cell phenotypes.  Integr Biol (Camb).  5(3).  523-34.
  • Si, F., Busiek, K., Margolin, W., Sun, S. (2013).  Organization of FtsZ Filaments in the Bacterial Division Ring Measured from Polarized Fluorescence Microscopy.  Biophysical Journal.  105(9).  1976-1986.
  • Stroka, K. M., Jiang, H., Tong, Z., Sun, S., Konstantopoulos, K. (2013).  Osmotic regulation of cell migration and volume in confined microenvironments.  Abstracts of Papers of the American Chemical Society.  245.
  • Chambliss, A. B., Wu, P., Chen, W., Sun, S., Wirtz, D. (2013).  Simultaneously defining cell phenotypes, cell cycle, and chromatin modifications at single-cell resolution.  Faseb Journal.  27(7).  2667-2676.
  • Yogurtcu, O. N., Kim, J., Sun, S. (2012).  A Mechanochemical Model of Actin Filaments.  Biophysical Journal.  103(4).  719-727.
  • Kim, D., Khatau, S. B., Feng, Y., Walcott, S., Sun, S., Longmore, G. D., Wirtz, D. (2012).  Actin cap associated focal adhesions and their distinct role in cellular mechanosensing.  Scientific Reports.  2.
  • Nilsen, N., Brownell, W. E., Sun, S., Spector, A. (2012).  Effect of membrane mechanics on charge transfer by the membrane protein prestin.  Biomechanics and Modeling in Mechanobiology.  11(1-2).  107-118.
  • Nilsen, N., Brownell, W. E., Sun, S., Spector, A. (2012).  Effect of membrane mechanics on charge transfer by the membrane protein prestin..  Biomech Model Mechanobiol.  11(1-2).  107-18.
  • Jiang, H., Sun, S. (2012).  Growth of curved and helical bacterial cells.  Soft Matter.  8(28).  7446-7451.
  • Lan, G., Sun, S. (2012).  Mechanochemical models of processive molecular motors.  Molecular Physics.  110(9-10).  1017-1034.
  • Sun, S., Jiang, H. (2012).  Physics of Bacterial Morphogenesis (vol 75, pg 543, 2011).  Microbiology and Molecular Biology Reviews.  76(1).  113-113.
  • Powers, R. J., Roy, S., Atilgan, E., Brownell, W. E., Sun, S., Gillespie, P. G., Spector, A. (2012).  Stereocilia Membrane Deformation: Implications for the Gating Spring and Mechanotransduction Channel.  Biophysical Journal.  102(2).  201-210.
  • Khatau, S. B., Bloom, R. J., Bajpai, S., Razafsky, D., Zang, S., Giri, A., Wu, P., Marchand, J., Celedon, A., Hale, C. M., Sun, S., Hodzic, D., Wirtz, D. (2012).  The distinct roles of the nucleus and nucleus-cytoskeleton connections in three-dimensional cell migration.  Scientific Reports.  2.
  • Harland, B., Walcott, S., Sun, S. (2011).  Adhesion dynamics and durotaxis in migrating cells.  Physical Biology.  8(1).
  • Jiang, H., Si, F., Margolin, W., Sun, S. (2011).  Mechanical Control of Bacterial Cell Shape.  Biophysical Journal.  101(2).  327-335.
  • Walcott, S., Kim, D., Wirz, D., Sun, S. (2011).  Nucleation and Decay Initiation Are the Stiffness-Sensitive Phases of Focal Adhesion Maturation.  Biophysical Journal.  101(12).  2919-2928.
  • Sun, S., Jiang, H. (2011).  Physics of Bacterial Morphogenesis.  Microbiology and Molecular Biology Reviews.  75(4).  543-565.
  • WALCOTT, S., SUN, S. (2010).  A mechanical model of actin stress fiber formation and substrate elasticity sensing in adherent cells.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.  107(17).  7757-7762.
  • Sun, S., Walcott, S. (2010).  Actin Crosslinkers: Repairing the Sense of Touch.  Current Biology.  20(20).  R895-R896.
  • Walcott, S., Sun, S. (2010).  Active force generation in cross-linked filament bundles without motor proteins.  Physical Review E.  82(5).
  • Sun, S., Walcott, S., Wolgemuth, C. (2010).  Cytoskeletal Cross-linking and Bundling in Motor-Independent Contraction.  Current Biology.  20(15).  R649-R654.
  • ESUE, O., RUPPRECHT, L., SUN, S., Wirtz, D. (2010).  Dynamics of the Bacterial Intermediate Filament Crescentin In Vitro and In Vivo.  PLOS ONE.  5(1).
  • Yogurtcu, O., Wolgemuth, C., Sun, S. (2010).  Mechanical Response and Conformational Amplification in alpha-Helical Coiled Coils.  Biophysical Journal.  99(12).  3895-3904.
  • DANIELS, B., DOBROWSKY, T., PERKINS, E., SUN, S., Wirtz, D. (2010).  MEX-5 enrichment in the C. elegans early embryo mediated by differential diffusion.  Development.  137(15).  2579-2585.
  • JIANG, H., SUN, S. (2010).  Morphology, Growth, and Size Limit of Bacterial Cells.  Physical Review Letters.  105(2).
  • Dobrowsky, T., Daniels, B., Siliciano, R., Sun, S., Wirtz, D. (2010).  Organization of Cellular Receptors into a Nanoscale Junction during HIV-1 Adhesion.  Plos Computational Biology.  6(7).
  • Celedon, A., Wirtz, D., Sun, S. (2010).  Torsional Mechanics of DNA Are Regulated by Small-Molecule Intercalation.  Journal of Physical Chemistry B.  114(50).  16929-16935.
  • HARLAND, B., BROWNELL, W., SPECTOR, A., SUN, S. (2010).  Voltage-induced bending and electromechanical coupling in lipid bilayers.  PHYSICAL REVIEW E.  81(3).
  • DANIELS, B., PERKINS, E., DOBROWSKY, T., SUN, S., Wirtz, D. (2009).  Asymmetric enrichment of PIE-1 in the Caenorhabditis elegans zygote mediated by binary counterdiffusion.  JOURNAL OF CELL BIOLOGY.  184(4).  473-479.
  • LAN, G., DANIELS, B., DOBROWSKY, T., Wirtz, D., SUN, S. (2009).  Condensation of FtsZ filaments can drive bacterial cell division.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.  106(1).  121-126.
  • KIM, J., SUN, S. (2009).  Continuum modeling of forces in growing viscoelastic cytoskeletal networks.  JOURNAL OF THEORETICAL BIOLOGY.  256(4).  596-606.
  • WALCOTT, S., SUN, S. (2009).  Hysteresis in cross-bridge models of muscle.  PHYSICAL CHEMISTRY CHEMICAL PHYSICS.  11(24).  4871-4881.
  • CELEDON, A., NODELMAN, I., WILDT, B., DEWAN, R., Searson, P., Wirtz, D., BOWMAN, G., SUN, S. (2009).  Magnetic Tweezers Measurement of Single Molecule Torque.  NANO LETTERS.  9(4).  1720-1725.
  • KIM, J., SUN, S. (2009).  Morphology of Caulobacter crescentus and the Mechanical Role of Crescentin.  BIOPHYSICAL JOURNAL.  96(8).  L47-L49.
  • HALE, C., SUN, S., Wirtz, D. (2009).  Resolving the Role of Actoymyosin Contractility in Cell Microrheology.  PLOS ONE.  4(9).
  • SUN, S., FARRELL, B., CHANA, M., OSTER, G., BROWNELL, W., SPECTOR, A. (2009).  Voltage and frequency dependence of prestin-associated charge transfer.  JOURNAL OF THEORETICAL BIOLOGY.  260(1).  137-144.
  • BAJPAI, S., CORREIA, J., FENG, Y., FIGUEIREDO, J., SUN, S., LONGMORE, G., SURIANO, G., Wirtz, D. (2008).  alpha-Catenin mediates initial E-cadherin-dependent cell-cell recognition and subsequent bond strengthening.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.  105(47).  18331-18336.
  • BLOOM, R., GEORGE, J., CELEDON, A., SUN, S., Wirtz, D. (2008).  Mapping local matrix remodeling induced by a migrating tumor cell using three-dimensional multiple-particle tracking.  BIOPHYSICAL JOURNAL.  95(8).  4077-4088.
  • DAJKOVIC, A., LAN, G., SUN, S., Wirtz, D., LUTKENHAUS, J. (2008).  MinC spatially controls bacterial cytokinesis by antagonizing the scaffolding function of FtsZ.  CURRENT BIOLOGY.  18(4).  235-244.
  • DOBROWSKY, T., ZHOU, Y., SUN, S., SILICIANO, R., Wirtz, D. (2008).  Monitoring early fusion dynamics of human immunodeficiency virus type 1 at single-molecule resolution.  JOURNAL OF VIROLOGY.  82(14).  7022-7033.
  • LAN, G., DAJKOVIC, A., Wirtz, D., SUN, S. (2008).  Polymerization and bundling kinetics of FtsZ filaments.  BIOPHYSICAL JOURNAL.  95(8).  4045-4056.
  • SUN, S., LAN, G., ATILGAN, E. (2008).  Stochastic Modeling Methods in Cell Biology.  BIOPHYSICAL TOOLS FOR BIOLOGISTS, VOL 2: IN VIVO TECHNIQUES.  89.  601-+.
  • CHOE, S., SUN, S. (2007).  Bending elasticity of anti-parallel beta-sheets.  BIOPHYSICAL JOURNAL.  92(4).  1204-1214.
  • HARLAND, B., SUN, S. (2007).  Path ensembles and path sampling in nonequilibrium stochastic systems.  JOURNAL OF CHEMICAL PHYSICS.  127.
  • TANSKANEN, A., GREENSTEIN, J., Chen, A., SUN, S., WINSLOW, R. (2007).  Protein geometry and placement in the cardiac dyad influence macroscopic properties of calcium-induced calcium release.  BIOPHYSICAL JOURNAL.  92(10).  3379-3396.
  • ATILGAN, E., SUN, S. (2007).  Shape transitions in lipid membranes and protein mediated vesicle fusion and fission.  JOURNAL OF CHEMICAL PHYSICS.  126(9).
  • LAN, G., WOLGEMUTH, C., SUN, S. (2007).  Z-ring force and cell shape during division in rod-like bacteria.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.  104.  16110-16115.
  • SUN, S. (2006).  Comment on "Path summation formulation of the master equation" - Reply.  PHYSICAL REVIEW LETTERS.  97(17).
  • WOLGEMUTH, C., SUN, S. (2006).  Elasticity of alpha-helical coiled coils.  PHYSICAL REVIEW LETTERS.  97(24).
  • LAN, G., SUN, S. (2006).  Flexible light-chain and helical structure of F-actin explain the movement and step size of myosin-VI.  BIOPHYSICAL JOURNAL.  91(11).  4002-4013.
  • ATILGAN, E., Wirtz, D., SUN, S. (2006).  Mechanics and dynamics of actin-driven thin membrane protrusions.  BIOPHYSICAL JOURNAL.  90(1).  65-76.
  • SUN, S., Wirtz, D. (2006).  Mechanics of enveloped virus entry into host cells.  BIOPHYSICAL JOURNAL.  90(1).  L10-L12.
  • SUN, S. (2006).  Path summation formulation of the master equation.  PHYSICAL REVIEW LETTERS.  96(21).
  • LAN, G., SUN, S. (2005).  Dynamics of myosin-driven skeletal muscle contraction: I. Steady-state force generation.  BIOPHYSICAL JOURNAL.  88(6).  4107-4117.
  • LAN, G., SUN, S. (2005).  Dynamics of myosin-V processivity.  BIOPHYSICAL JOURNAL.  88(2).  999-1008.
  • ATILGAN, E., Wirtz, D., SUN, S. (2005).  Morphology of the lamellipodium and organization of actin filaments at the leading edge of crawling cells.  BIOPHYSICAL JOURNAL.  89(5).  3589-3602.
  • CHOE, S., SUN, S. (2005).  The elasticity of alpha-helices.  JOURNAL OF CHEMICAL PHYSICS.  122(24).
  • SUN, S., WANG, H., OSTER, G. (2004).  Asymmetry in the F-1-ATPase and its implications for the rotational cycle.  BIOPHYSICAL JOURNAL.  86(3).  1373-1384.
  • ATILGAN, E., SUN, S. (2004).  Equilibrium free energy estimates based on nonequilibrium work relations and extended dynamics.  JOURNAL OF CHEMICAL PHYSICS.  121(21).  10392-10400.
  • LIAO, J., Sun, S., CHANDLER, D., OSTER, G. (2004).  The conformational states of Mg center dot ATP in water.  EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS.  33(1).  29-37.
  • Sun, S., CHANDLER, D., DINNER, A., OSTER, G. (2003).  Elastic energy storage in beta-sheets with application to F-1-ATPase.  EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS.  32(8).  676-683.
  • SUN, S. (2003).  Equilibrium free energies from path sampling of nonequilibrium trajectories.  JOURNAL OF CHEMICAL PHYSICS.  118(13).  5769-5775.
  • TEN WOLDE, P., SUN, S., CHANDLER, D. (2002).  Model of a fluid at small and large length scales and the hydrophobic effect.  PHYSICAL REVIEW E.  65(1).
  • SUN, S., MILLER, W. (2002).  Statistical sampling of semiclassical distributions: Calculating quantum mechanical effects using Metropolis Monte Carlo.  JOURNAL OF CHEMICAL PHYSICS.  117(12).  5522-5528.
  • SUN, S. (2001).  Weighted density functional theory of the solvophobic effect.  PHYSICAL REVIEW E.  64(2).
  • SUN, S. (2000).  Semiclassical approximations to real-time quantum-mechanical effects in correlation functions of complex molecular systems.  JOURNAL OF CHEMICAL PHYSICS.  112(19).  8241-8251.
  • Sun, X., MILLER, W. (1999).  Forward-backward initial value representation for semiclassical time correlation functions.  JOURNAL OF CHEMICAL PHYSICS.  110(14).  6635-6644.
  • Sun, X., MILLER, W. (1999).  Forward-backward initial value representation for semiclassical time correlation functions (vol 110, 6635, 1999).  JOURNAL OF CHEMICAL PHYSICS.  111(4).  1788-1788.
  • Sun, X., WANG, H., MILLER, W. (1998).  On the semiclassical description of quantum coherence in thermal rate constants.  JOURNAL OF CHEMICAL PHYSICS.  109(11).  4190-4200.
  • WANG, H., Sun, X., MILLER, W. (1998).  Semiclassical approximations for the calculation of thermal rate constants for chemical reactions in complex molecular systems.  JOURNAL OF CHEMICAL PHYSICS.  108(23).  9726-9736.
  • Sun, X., MILLER, W. (1998).  Semiclassical initial value representation for rotational degrees of freedom: The tunneling dynamics of HCl dimer.  JOURNAL OF CHEMICAL PHYSICS.  108(21).  8870-8877.
  • Sun, X., WANG, H., MILLER, W. (1998).  Semiclassical theory of electronically nonadiabatic dynamics: Results of a linearized approximation to the initial value representation.  JOURNAL OF CHEMICAL PHYSICS.  109(17).  7064-7074.
  • Sun, X., MILLER, W. (1997).  Mixed semiclassical-classical approaches to the dynamics of complex molecular systems.  JOURNAL OF CHEMICAL PHYSICS.  106(3).  916-927.
  • Sun, X., MILLER, W. (1997).  Semiclassical initial value representation for electronically nonadiabatic molecular dynamics.  JOURNAL OF CHEMICAL PHYSICS.  106(15).  6346-6353.
Books
  • Sun, S., Farrell, B., Chana, M., Feng, S., Oster, G., Brownell, W., Spector, A., Cooper, N., Kemp, D. (2009).  VOLTAGE AND FREQUENCY DEPENDENCE OF CHARGE TRANSFER BY PRESTIN: AN ELECTRO-DIFFUSION MODEL.  385-390.
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