Faculty

Sean Sun

Professor

Research Interests

Mechanobiology of the cell, molecular biomechanics and biophysics, molecular motors and muscle, statistical mechanics and nonlinear phenomena.

Education
  • Ph.D. 1998, Univ of California Berkeley
Experience
  • 2008 - 2008:  Platform session chair, ACS
  • 2008 - 2008:  Platform session chair, BMES
  • 2007 - 2007:  Platform session chair, BMES
  • 2006 - 2006:  Platform session chair, BMES
  • 2003 - 2003:  Session Chair, ACS
Research Areas
  • Cell Mobility
  • Molecular Motors
  • Proteins and Membranes
  • STATISTICAL mechanics
  • Theoretical biomechanics and biophysics
Awards
  • 2017:  Fellow
  • 2016:  Fellow
  • 2015:  Johns Hopkins President's Frontier Finalist
  • 2010:  Alexander von Humboldt Fellowship
  • 2009:  Johns Hopkins University Faculty Scholar
  • 2006:  National Science Foundation CAREER Award
  • 1992:  Eberly College of Science Scholar - Pennsylvania State University
  • 1990:  University Scholar - Pennsylvania State University
Journal Articles
  • Li Y, Sun SX (2018).  Transition from Actin-Driven to Water-Driven Cell Migration Depends on External Hydraulic Resistance.  Biophysical Journal.  114(12).
  • Rochman ND, Popescu DM, Sun SX (2018).  Ergodicity, hidden bias and the growth rate gain.  Physical Biology.  15(3).
  • He L, Tao J, Maity D, Si F, Wu Y, Wu T, Prasath V, Wirtz D, Sun SX (2018).  Role of membrane-tension gated Ca2+ flux in cell mechanosensation.  Journal of Cell Science.  131(4).
  • Li Y, He L, Gonzalez NAP, Graham J, Wolgemuth C, Wirtz D, Sun SX (2017).  Going with the Flow: Water Flux and Cell Shape during Cytokinesis.  Biophysical Journal.  113(11).
  • Tao J, Li Y, Vig DK, Sun SX (2017).  Cell mechanics: A dialogue.  Reports on Progress in Physics.  80(3).
  • Loza AJ, Koride S, Schimizzi GV, Li B, Sun SX, Longmore GD (2016).  Cell density and actomyosin contractility control the organization of migrating collectives within an epithelium.  Molecular Biology of the Cell.  27(22).
  • Rochman ND, Sun SX (2016).  The twisted tauopathies: Surface interactions of helically patterned filaments seen in Alzheimer's disease and elsewhere.  Soft Matter.  12(3).
  • Li Y, Mori Y, Sun SX (2015).  Flow-Driven Cell Migration under External Electric Fields.  Physical Review Letters.  115(26).
  • Tao J, Sun SX (2015).  Active Biochemical Regulation of Cell Volume and a Simple Model of Cell Tension Response.  Biophysical Journal.  109(8).
  • Smith Q, Stukalin E, Kusuma S, Gerecht S, Sun SX (2015).  Stochasticity and Spatial Interaction Govern Stem Cell Differentiation Dynamics.  Scientific Reports.  5.
  • Si F, Li B, Margolin W, Sun SX (2015).  Bacterial growth and form under mechanical compression.  Scientific Reports.  5.
  • Harland B, Lee Wh, Brownell WE, Sun SX, Spector AA (2015).  The potential and electric field in the cochlear outer hair cell membrane.  Medical and Biological Engineering and Computing.  53(5).
  • Valencia AMJ, Wu PH, Yogurtcu ON, Rao P, DiGiacomo J, Godet I, He L, Lee MH, Gilkes D, Sun SX, Wirtz D (2015).  Collective cancer cell invasion induced by coordinated contractile stresses.  Oncotarget.  6(41).
  • Kim DH, Li B, Si F, Phillip JM, Wirtz D, Sun SX (2015).  Volume regulation and shape bifurcation in the cell nucleus.  Journal of Cell Science.  128(18).
  • Li B, Sun SX (2014).  Coherent motions in confluent cell monolayer sheets.  Biophysical Journal.  107(7).
  • Powers RJ, Kulason S, Atilgan E, Brownell WE, Sun SX, Barr-Gillespie PG, Spector AA (2014).  The local forces acting on the mechanotransduction channel in hair cell stereocilia.  Biophysical Journal.  106(11).
  • Stroka KM, Jiang H, Chen SH, Tong Z, Wirtz D, Sun SX, Konstantopoulos K (2014).  Water permeation drives tumor cell migration in confined microenvironments.  Cell.  157(3).
  • Wu PH, Giri A, Sun SX, Wirtz D (2014).  Three-dimensional cell migration does not follow a random walk.  Proceedings of the National Academy of Sciences of the United States of America.  111(11).
  • Stroka KM, Jiang H, Chen S, Tong Z, Wirtz D, Sun S, Konstantopoulos K (2014).  Water Permeation Drives Tumor Cell Migration in Confined Microenvironments.  Cell.  157(3).  611-623.
  • Stroka KM, Jiang H, Chen S, Tong Z, Wirtz D, Sun S, Konstantopoulos K (2014).  Water permeation drives tumor cell migration in confined microenvironments.  Cell.  157(3).  611-23.
  • Koride S, He L, Xiong L, Lan G, Montell DJ, Sun S (2014).  Mechanochemical regulation of oscillatory follicle cell dynamics in the developing Drosophila egg chamber.  Molecular Biology of the Cell.  25(22).  3709-3716.
  • Powers RJ, Kulason S, Atilgan E, Brownell WE, Sun S, Barr-Gillespie PG, Spector A (2014).  The Local Forces Acting on the Mechanotransduction Channel in Hair Cell Stereocilia.  Biophysical Journal.  106(11).  2519-2528.
  • Li B, Sun S (2014).  Coherent Motions in Confluent Cell Monolayer Sheets.  Biophysical Journal.  107(7).  1532-1541.
  • Wu P, Giri A, Sun S, Wirtz D (2014).  Three-dimensional cell migration does not follow a random walk.  Proceedings of the National Academy of Sciences of the United States of America.  111(11).  3949-3954.
  • Stroka KM, Gu Z, Sun S, Konstantopoulos K (2014).  Bioengineering paradigms for cell migration in confined microenvironments.  Curr Opin Cell Biol.  30.  41-50.
  • Stroka KM, Gu Z, Sun S, Konstantopoulos K (2014).  Bioengineering paradigms for cell migration in confined microenvironments.  Current Opinion in Cell Biology.  30.  41-50.
  • Koride S, He L, Xiong LP, Lan G, Montell DJ, Sun SX (2014).  Mechanochemical regulation of oscillatory follicle cell dynamics in the developing Drosophila egg chamber.  Molecular Biology of the Cell.  25(22).
  • Stroka KM, Gu Z, Sun SX, Konstantopoulos K (2014).  Bioengineering paradigms for cell migration in confined microenvironments.  Current Opinion in Cell Biology.  30(1).
  • Sun S (2014).  How Accurately Can a Single Receptor Measure Ligand Concentrations?.  Biophysical Journal.  106(4).  778-779.
  • Si F, Busiek K, Margolin W, Sun SX (2013).  Organization of FtsZ filaments in the bacterial division ring measured from polarized fluorescence microscopy.  Biophysical Journal.  105(9).
  • Jiang H, Sun SX (2013).  Cellular pressure and volume regulation and implications for cell mechanics.  Biophysical Journal.  105(3).
  • Stukalin EB, Aifuwa I, Kim JS, Wirtz D, Sun SX (2013).  Age-dependent stochastic models for understanding population fluctuations in continuously cultured cells.  Journal of the Royal Society Interface.  10(85).
  • Chambliss AB, Wu PH, Chen WC, Sun SX, Wirtz D (2013).  Simultaneously defining cell phenotypes, cell cycle, and chromatin modifications at single-cell resolution.  FASEB Journal.  27(7).
  • Chen WC, Wu PH, Phillip JM, Khatau SB, Choi JM, Dallas MR, Konstantopoulos K, Sun SX, Lee JSH, Hodzic D, Wirtz D (2013).  Functional interplay between the cell cycle and cell phenotypes.  Integrative Biology (United Kingdom).  5(3).
  • Stroka KM, Jiang H, Sun SX, Konstantopoulos K (2013).  Role of water permeation in confined cell migration and polarization.  Food, Pharmaceutical and Bioengineering Division 2013 - Core Programming Area at the 2013 AIChE Annual Meeting: Global Challenges for Engineering a Sustainable Future.
  • Jiang H, Sun S (2013).  Cellular Pressure and Volume Regulation and Implications for Cell Mechanics.  Biophysical Journal.  105(3).  609-619.
  • Stukalin EB, Aifuwa I, Kim J, Wirtz D, Sun S (2013).  Age-dependent stochastic models for understanding population fluctuations in continuously cultured cells.  Journal of the Royal Society Interface.  10(85).
  • Si F, Busiek K, Margolin W, Sun S (2013).  Organization of FtsZ Filaments in the Bacterial Division Ring Measured from Polarized Fluorescence Microscopy.  Biophysical Journal.  105(9).  1976-1986.
  • Chambliss AB, Wu P, Chen W, Sun S, Wirtz D (2013).  Simultaneously defining cell phenotypes, cell cycle, and chromatin modifications at single-cell resolution.  Faseb Journal.  27(7).  2667-2676.
  • Chen W, Wu PH, Phillip JM, Khatau SB, Choi J, Dallas MR, Konstantopoulos K, Sun S, Lee JS, Hodzic D, Wirtz D (2013).  Functional interplay between the cell cycle and cell phenotypes.  Integr Biol (Camb).  5(3).  523-34.
  • Chen W, Wu P, Phillip JM, Khatau SB, Choi JM, Dallas MR, Konstantopoulos K, Sun S, Lee JS, Hodzic D, Wirtz D (2013).  Functional interplay between the cell cycle and cell phenotypes.  Integrative Biology.  5(3).  523-534.
  • Stroka KM, Jiang H, Tong Z, Sun S, Konstantopoulos K (2013).  Osmotic regulation of cell migration and volume in confined microenvironments.  Abstracts of Papers of the American Chemical Society.  245.
  • Yogurtcu ON, Kim JS, Sun SX (2012).  A mechanochemical model of actin filaments.  Biophysical Journal.  103(4).
  • Kim DH, Khatau SB, Feng Y, Walcott S, Sun SX, Longmore GD, Wirtz D (2012).  Actin cap associated focal adhesions and their distinct role in cellular mechanosensing.  Scientific Reports.  2.
  • Jiang H, Sun SX (2012).  Growth of curved and helical bacterial cells.  Soft Matter.  8(28).
  • Khatau SB, Bloom RJ, Bajpai S, Razafsky D, Zang S, Giri A, Wu PH, Marchand J, Celedon A, Hale CM, Sun SX, Hodzic D, Wirtz D (2012).  The distinct roles of the nucleus and nucleus-cytoskeleton connections in three-dimensional cell migration.  Scientific Reports.  2.
  • Lan G, Sun SX (2012).  Mechanochemical models of processive molecular motors.  Molecular Physics.  110(9-10).
  • Powers RJ, Roy S, Atilgan E, Brownell WE, Sun SX, Gillespie PG, Spector AA (2012).  Stereocilia membrane deformation: Implications for the gating spring and mechanotransduction channel.  Biophysical Journal.  102(2).
  • Sun S, Jiang H (2012).  Physics of Bacterial Morphogenesis (vol 75, pg 543, 2011).  Microbiology and Molecular Biology Reviews.  76(1).  113-113.
  • Nilsen N, Brownell WE, Sun S, Spector A (2012).  Effect of membrane mechanics on charge transfer by the membrane protein prestin..  Biomech Model Mechanobiol.  11(1-2).  107-18.
  • Yogurtcu ON, Kim J, Sun S (2012).  A Mechanochemical Model of Actin Filaments.  Biophysical Journal.  103(4).  719-727.
  • Nilsen N, Brownell WE, Sun S, Spector A (2012).  Effect of membrane mechanics on charge transfer by the membrane protein prestin.  Biomechanics and Modeling in Mechanobiology.  11(1-2).  107-118.
  • Jiang H, Sun S (2012).  Growth of curved and helical bacterial cells.  Soft Matter.  8(28).  7446-7451.
  • Lan G, Sun S (2012).  Mechanochemical models of processive molecular motors.  Molecular Physics.  110(9-10).  1017-1034.
  • Powers RJ, Roy S, Atilgan E, Brownell WE, Sun S, Gillespie PG, Spector A (2012).  Stereocilia Membrane Deformation: Implications for the Gating Spring and Mechanotransduction Channel.  Biophysical Journal.  102(2).  201-210.
  • Kim D, Khatau SB, Feng Y, Walcott S, Sun S, Longmore GD, Wirtz D (2012).  Actin cap associated focal adhesions and their distinct role in cellular mechanosensing.  Scientific Reports.  2.
  • Khatau SB, Bloom RJ, Bajpai S, Razafsky D, Zang S, Giri A, Wu P, Marchand J, Celedon A, Hale CM, Sun S, Hodzic D, Wirtz D (2012).  The distinct roles of the nucleus and nucleus-cytoskeleton connections in three-dimensional cell migration.  Scientific Reports.  2.
  • Nilsen N, Brownell WE, Sun SX, Spector AA (2012).  Effect of membrane mechanics on charge transfer by the membrane protein prestin.  Biomechanics and Modeling in Mechanobiology.  11(1-2).
  • Walcott S, Kim DH, Wirz D, Sun SX (2011).  Nucleation and Decay initiation are the stiffness-sensitive phases of focal adhesion maturation.  Biophysical Journal.  101(12).
  • Sun SX, Jiang H (2011).  Physics of bacterial morphogenesis.  Microbiology and Molecular Biology Reviews.  75(4).
  • Jiang H, Si F, Margolin W, Sun SX (2011).  Mechanical control of bacterial cell shape.  Biophysical Journal.  101(2).
  • Sun S, Jiang H (2011).  Physics of Bacterial Morphogenesis.  Microbiology and Molecular Biology Reviews.  75(4).  543-565.
  • Harland B, Walcott S, Sun SX (2011).  Adhesion dynamics and durotaxis in migrating cells.  Physical Biology.  8(1).
  • Harland B, Walcott S, Sun S (2011).  Adhesion dynamics and durotaxis in migrating cells.  Physical Biology.  8(1).
  • Jiang H, Si F, Margolin W, Sun S (2011).  Mechanical Control of Bacterial Cell Shape.  Biophysical Journal.  101(2).  327-335.
  • Walcott S, Kim D, Wirz D, Sun S (2011).  Nucleation and Decay Initiation Are the Stiffness-Sensitive Phases of Focal Adhesion Maturation.  Biophysical Journal.  101(12).  2919-2928.
  • Celedon A, Wirtz D, Sun S (2010).  Torsional mechanics of DNA are regulated by small-molecule intercalation.  Journal of Physical Chemistry B.  114(50).
  • Yogurtcu ON, Wolgemuth CW, Sun SX (2010).  Mechanical response and conformational amplification in α-Helical coiled coils.  Biophysical Journal.  99(12).
  • Walcott S, Sun SX (2010).  Active force generation in cross-linked filament bundles without motor proteins.  Physical Review E - Statistical, Nonlinear, and Soft Matter Physics.  82(5).
  • Sun SX, Walcott S (2010).  Actin crosslinkers: Repairing the sense of touch.  Current Biology.  20(20).
  • Sun SX, Walcott S, Wolgemuth CW (2010).  Cytoskeletal cross-linking and bundling in motor-independent contraction.  Current Biology.  20(15).
  • Daniels BR, Dobrowsky TM, Perkins EM, Sun SX, Wirtz D (2010).  MEX-5 enrichment in the C. elegans early embryo mediated by differential diffusion.  Development.  137(15).
  • Jiang H, Sun SX (2010).  Morphology, growth, and size limit of bacterial cells.  Physical Review Letters.  105(2).
  • Dobrowsky TM, Daniels BR, Siliciano RF, Sun SX, Wirtz D (2010).  Organization of cellular receptors into a nanoscale junction during HIV-1 adhesion.  PLoS Computational Biology.  6(7).
  • Walcott S, Sun SX (2010).  A mechanical model of actin stress fiber formation and substrate elasticity sensing in adherent cells.  Proceedings of the National Academy of Sciences of the United States of America.  107(17).
  • Harland B, Brownell WE, Spector AA, Sun SX (2010).  Voltage-induced bending and electromechanical coupling in lipid bilayers.  Physical Review E - Statistical, Nonlinear, and Soft Matter Physics.  81(3).
  • Esue O, Rupprecht L, Sun SX, Wirtz D (2010).  Dynamics of the bacterial intermediate filament crescentin in vitroand in vivo.  PLoS ONE.  5(1).
  • Celedon A, Wirtz D, Sun S (2010).  Torsional Mechanics of DNA Are Regulated by Small-Molecule Intercalation.  Journal of Physical Chemistry B.  114(50).  16929-16935.
  • Hale CM, Sun SX, Wirtz D (2009).  Resolving the role of actoymyosin contractility in cell microrheology.  PLoS ONE.  4(9).
  • Sun SX, Farrell B, Chana MS, Oster G, Brownell WE, Spector AA (2009).  Voltage and frequency dependence of prestin-associated charge transfer.  Journal of Theoretical Biology.  260(1).
  • Walcott S, Sun SX (2009).  Hysteresis in cross-bridge models of muscle.  Physical Chemistry Chemical Physics.  11(24).
  • Jin SK, Sun SX (2009).  Morphology of Caulobacter crescentus and the mechanical role of crescentin.  Biophysical Journal.  96(8).
  • Celedon A, Nodelman IM, Wildt B, Dewan R, Searson P, Wirtz D, Bowman GD, Sun SX (2009).  Magnetic tweezers measurement of single molecule torque.  Nano Letters.  9(4).
  • Daniels BR, Perkins EM, Dobrowsky TM, Sun SX, Wirtz D (2009).  Asymmetric enrichment of PIE-1 in the Caenorhabditis elegans zygote mediated by binary counterdiffusion.  Journal of Cell Biology.  184(4).
  • Kim JS, Sun SX (2009).  Continuum modeling of forces in growing viscoelastic cytoskeletal networks.  Journal of Theoretical Biology.  256(4).
  • Lan G, Daniels BR, Dobrowsky TM, Wirtz D, Sun SX (2009).  Condensation of FtsZ filaments can drive bacterial cell division.  Proceedings of the National Academy of Sciences of the United States of America.  106(1).
  • Sun SX, Lan G, Atilgan E (2008).  Chapter 23 Stochastic Modeling Methods in Cell Biology.  Methods in Cell Biology.  89.
  • Bajpai S, Correia J, Feng Y, Figueiredo J, Sun SX, Longmore GD, Suriano G, Wirtz D (2008).  α-Catenin mediates initial E-cadherin-dependent cell- cell recognition and subsequent bond strengthening.  Proceedings of the National Academy of Sciences of the United States of America.  105(47).
  • Bloom RJ, George JP, Celedon A, Sun SX, Wirtz D (2008).  Mapping local matrix remodeling induced by a migrating tumor cell using three-dimensional multiple-particle tracking.  Biophysical Journal.  95(8).
  • Lan G, Dajkovic A, Wirtz D, Sun SX (2008).  Polymerization and bundling kinetics of FtsZ filaments.  Biophysical Journal.  95(8).
  • Dobrowsky TM, Zhou Y, Sun SX, Siliciano RF, Wirtz D (2008).  Monitoring early fusion dynamics of human immunodeficiency virus type 1 at single-molecule resolution.  Journal of Virology.  82(14).
  • Dajkovic A, Lan G, Sun SX, Wirtz D, Lutkenhaus J (2008).  MinC Spatially Controls Bacterial Cytokinesis by Antagonizing the Scaffolding Function of FtsZ.  Current Biology.  18(4).
  • Lan G, Wolgemuth CW, Sun SX (2007).  Z-ring force and cell shape during division in rod-like bacteria.  Proceedings of the National Academy of Sciences of the United States of America.  104(41).
  • Harland B, Sun SX (2007).  Path ensembles and path sampling in nonequilibrium stochastic systems.  Journal of Chemical Physics.  127(10).
  • Atilgan E, Sun SX (2007).  Shape transitions in lipid membranes and protein mediated vesicle fusion and fission.  Journal of Chemical Physics.  126(9).
  • Choe S, Sun SX (2007).  Bending elasticity of anti-parallel β-sheets.  Biophysical Journal.  92(4).
  • Tanskanen AJ, Greenstein JL, Chen A, Sun SX, Winslow RL (2007).  Protein geometry and placement in the cardiac dyad influence macroscopic properties of calcium-induced calcium release.  Biophysical Journal.  92(10).
  • Wolgemuth CW, Sun SX (2006).  Elasticity of α-helical coiled coils.  Physical Review Letters.  97(24).
  • Sun SX (2006).  Path summation formulation of the master equation.  Physical Review Letters.  96(21).
  • Sun SX, Wirtz D (2006).  Mechanics of enveloped virus entry into host cells.  Biophysical Journal.  90(1).
  • Lan G, Sun SX (2006).  Flexible light-chain and helical structure of F-actin explain the movement and step size of myosin-VI.  Biophysical Journal.  91(11).
  • Atilgan E, Wirtz D, Sun SX (2006).  Mechanics and dynamics of actin-driven thin membrane protrusions.  Biophysical Journal.  90(1).
  • Choe S, Sun SX (2005).  The elasticity of α-helices.  Journal of Chemical Physics.  122(24).
  • Choe S, Sun SX (2005).  The elasticity of alpha-helices..  The Journal of chemical physics.  122(24).
  • Atilgan E, Wirtz D, Sun SX (2005).  Morphology of the lamellipodium and organization of actin filaments at the leading edge of crawling cells.  Biophysical Journal.  89(5).
  • Lan G, Sun SX (2005).  Dynamics of myosin-V processivity.  Biophysical Journal.  88(2).
  • Lan G, Sun SX (2005).  Dynamics of myosin-driven skeletal muscle contraction: I. Steady-state force generation.  Biophysical Journal.  88(6).
  • Atilgan E, Sun SX (2004).  Equilibrium free energy estimates based on nonequilibrium work relations and extended dynamics.  Journal of Chemical Physics.  121(21).
  • Liao JC, Sun S, Chandler D, Oster G (2004).  The conformational states of Mg·ATP in water.  European Biophysics Journal.  33(1).
  • Sun SX, Wang H, Oster G (2004).  Asymmetry in the F1-ATPase and Its implications for the Rotational Cycle.  Biophysical Journal.  86(3).
  • LIAO J, Sun S, CHANDLER D, OSTER G (2004).  The conformational states of Mg center dot ATP in water.  EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS.  33(1).  29-37.
  • Sun S, Chandler D, Dinner AR, Oster G (2003).  Elastic energy storage in β-sheets with application to F1-ATPase.  European Biophysics Journal.  32(8).
  • Sun SX (2003).  Equilibrium free energies from path sampling of nonequilibrium trajectories.  Journal of Chemical Physics.  118(13).
  • Sun S, CHANDLER D, DINNER A, OSTER G (2003).  Elastic energy storage in beta-sheets with application to F-1-ATPase.  EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS.  32(8).  676-683.
  • Sun SX, Miller WH (2002).  Statistical sampling of semiclassical distributions: Calculating quantum mechanical effects using Metropolis Monte Carlo.  Journal of Chemical Physics.  117(12).
  • Sun SX (2000).  Semiclassical approximations to real-time quantum-mechanical effects in correlation functions of complex molecular systems.  Journal of Chemical Physics.  112(19).
Books
  • Sun S, Farrell B, Chana M, Feng S, Oster G, Brownell W, Spector A, Cooper N, Kemp D (2009).  VOLTAGE AND FREQUENCY DEPENDENCE OF CHARGE TRANSFER BY PRESTIN: AN ELECTRO-DIFFUSION MODEL.  385-390.
Book Chapters
  • Sun SX (2012).  Biophysics of bacterial cell growth and division.  Comprehensive Biophysics.  7.
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