Ishan Barman

Assistant Professor

Research Interests

Bioengineering, optics and spectroscopy, developing integrative photonics solutions to complex problems in biological research and medical diagnosis. Advancement of photonics methods for applications in clinical diagnosis. Comprehensive characterization of biomolecules, investigation of pharmaceutical drugs and their interaction with biological systems, and rapid measurements in microfluidic platforms.

  • Ph.D. 2011, Massachusetts Institute of Technology
  • M.S. 2007, Massachusetts Institute of Technology
  • (B.Tech.) 2005, Indian Institute of Technology
  • 2014 - 2014:  Visiting Professor, Gdansk University of Technology, Poland
  • 2011 - 2013:  Postdoctoral Fellow, Laser Biomedical Research Center, MIT
Research Areas
  • Bioengineering; Biophotonics; Spectroscopic Imaging
  • Analytical Chemistry; Raman Scattering; Chemometrics; Plasmonics
  • Mechanobiology; Microfluidics; Cellular Manipulation
  • Clinical Diagnostics; Cancer detection
  • 2016:  Outstanding Young Engineer
  • 2016:  Emerging Investigator in Analytical Chemistry
  • 2014:  Dr. Horace Furumoto Innovations Young Investigator Award
  • 2014:  FACSS Innovation Award FInalist
  • 2014:  Visiting Professor
  • 2013:  Royal Society of Chemistry (RSC) Analytical Division Award
  • 2011:  Gordon F. Kirkbright Bursary Award
  • 2010:  Tomas A. Hirschfeld Award, FACSS
  • 2009:  SPIE Research Excelllence Award
  • 2005:  Institute Silver Medal - IIT
  • 2004:  H. P. Bhadury Memorial Prize - IIT Kharagpur
  • 2004:  J. C. Ghosh Memorial Prize - IIT Kharagpur
Journal Articles
  • Jin, Q., Li , M., Polat, B., Paidi, S. K., Dai, A., Zhang, A., Pagaduan, J. V., Barman, I., Gracias, D. (2017).  Mechanical Trap Surface-Enhanced Raman Spectroscopy for Three-Dimensional Surface Molecular Imaging of Single Live Cells..  Angewandte Chemie (International ed. in English).
  • Winnard, Jr, P. T., Zhang, C., Vesuna, F., Kang, J. W., Garry, J., Dasari, R. R., Barman, I., Raman, V. (2017).  Organ-specific isogenic metastatic breast cancer cell lines exhibit distinct Raman spectral signatures and metabolomes..  Oncotarget.
  • Paidi, S. K., Rizwan, A., Zheng, C., Cheng, M., Glunde, K., Barman, I. (2017).  Label-Free Raman Spectroscopy Detects Stromal Adaptations in Premetastatic Lungs Primed by Breast Cancer..  Cancer research.  77(2).  247-256.
  • Pandey, R., Paidi, S. K., Valdez, T. A., Zhang, C., Spegazzini, N., Dasari, R. R., Barman, I. (2017).  Noninvasive Monitoring of Blood Glucose with Raman Spectroscopy..  Accounts of chemical research.
  • Siddhanta, S., Paidi, S. K., Bushley, K., Prasad, R., Barman, I. (2017).  Exploring Morphological and Biochemical Linkages in Fungal Growth with Label-Free Light Sheet Microscopy and Raman Spectroscopy..  Chemphyschem : a European journal of chemical physics and physical chemistry.  18(1).  72-78.
  • Aziz, N., Pandey, R., Barman, I., Prasad, R. (2016).  Leveraging the Attributes of Mucor hiemalis-Derived Silver Nanoparticles for a Synergistic Broad-Spectrum Antimicrobial Platform..  Frontiers in microbiology.  7.  1984.
  • Singh, S. P., Fält, P., Barman, I., Koistinen, A., Dasari, R. R., Kullaa, A. M. (2016).  Objective identification of dental abnormalities with multispectral fluorescence imaging..  Journal of biophotonics.
  • Li, M., Ray, S., Pomper, M., Barman, I. (2016).  Ultrahigh affinity Raman probe for targeted live cell imaging of prostate cancer.  Chemical Science (Royal Society of Chemistry : 2010).  7.  6779 – 6785.
  • Siddhanta, S., Wróbel, M. S., Barman, I. (2016).  Integration of protein tethering in a rapid and label-free SERS screening platform for drugs of abuse..  Chemical communications (Cambridge, England).  52(58).  9016-9.
  • Myakalwar, A. K., Anubham, S. K., Paidi, S. K., Barman, I., Gundawar, M. K. (2016).  Real-time fingerprinting of structural isomers using laser induced breakdown spectroscopy..  The Analyst.  141(10).  3077-83.
  • Paidi, S. K., Siddhanta, S., Strouse, R., McGivney, J. B., Larkin, C., Barman, I. (2016).  Rapid Identification of Biotherapeutics with Label-Free Raman Spectroscopy..  Analytical chemistry.  88(8).  4361-4368.
  • Siddhanta, S., Zheng, C., Narayana, C., Barman, I. (2016).  An impediment to random walk: Trehalose microenvironment drives preferential endocytic uptake of plasmonic nanoparticles.  Chemical Science (Royal Society of Chemistry : 2010).  7.  3730-3736.
  • Haka, A. S., Sue, E., Zhang, C., Bhardwaj, P., Sterling, J., Carpenter, C., Leonard, M., Manzoor, M., Walker, J., Aleman, J. O., Gareau, D., Holt, P. R., Breslow, J. L., Zhou, X., Giri, D., Morrow, M., Iyengar, N., Barman, I., Hudis, C. A., Dannenberg, A. J. (2016).  Noninvasive Detection of Inflammatory Changes in White Adipose Tissue by Label-Free Raman Spectroscopy..  Analytical chemistry.  88(4).  2140-2148.
  • Pandey, R., Dingari, N. C., Spegazzini, N., Dasari, R. R., Horowitz, G. L., Barman, I. (2015).  Emerging trends in optical sensing of glycemic markers for diabetes monitoring.  TrAC Trends in Analytical Chemistry.  64.  100-108.
  • Zheng, C., Shao, W., Paidi, S. K., Han, B., Fu, T., Wu, D., Bi, L., Xu, W., Fan, Z., Barman, I. (2015).  Pursuing shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS) for concomitant detection of breast lesions and microcalcifications..  Nanoscale.  7(40).  16960-8.
  • Aziz, N., Faraz, M., Pandey, R., Shakir, M., Fatma, T., Varma, A., Barman, I., Prasad, R. (2015).  Facile Algae-Derived Route to Biogenic Silver Nanoparticles: Synthesis, Antibacterial, and Photocatalytic Properties..  Langmuir : the ACS journal of surfaces and colloids.  31(42).  11605-12.
  • Siddhanta, S., Barman, I., Narayana, C. (2015).  Revealing the trehalose mediated inhibition of protein aggregation through lysozyme-silver nanoparticle interaction..  Soft matter.  11(37).  7241-9.
  • Pandey, R., Paidi, S. K., Kang, J., Spegazzini, N., Dasari, R. R., Valdez, T. A., Barman, I. (2015).  Discerning the differential molecular pathology of proliferative middle ear lesions using Raman spectroscopy..  Scientific reports.  5.  13305.
  • Kumar Myakalwar, A., Spegazzini, N., Zhang, C., Kumar Anubham, S., Dasari, R. R., Barman, I., Kumar Gundawar, M. (2015).  Less is more: Avoiding the LIBS dimensionality curse through judicious feature selection for explosive detection..  Scientific reports.  5.  13169.
  • Prasad, R., Pandey, R., Barman, I. (2015).  Engineering tailored nanoparticles with microbes: quo vadis?.  Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology.
  • Li , M., Kang, J., Sukumar, S., Dasari, R. R., Barman, I. (2015).  Multiplexed detection of serological cancer markers with plasmon-enhanced Raman spectro-immunoassay..  Chemical science (Royal Society of Chemistry : 2010).  6(7).  3906-3914.
  • Valdez, T. A., Spegazzini, N., Pandey, R., Longo, K., Grindle, C., Peterson, D., Barman, I. (2015).  Multi-color reflectance imaging of middle ear pathology in vivo..  Analytical and bioanalytical chemistry.  407(12).  3277-83.
  • Sathyavathi, R., Saha, A., Soares, J. S., Spegazzini, N., McGee, S., Rao Dasari, R., Fitzmaurice, M., Barman, I. (2015).  Raman spectroscopic sensing of carbonate intercalation in breast microcalcifications at stereotactic biopsy..  Scientific reports.  5.  9907.
  • Li, M., Kang, J. W., Dasari, R. R., Barman, I. (2014).  Shedding Light on the Extinction-Enhancement Duality in Gold Nanostar-Enhanced Raman Spectroscopy.  Angewandte Chemie.  126(51).  14339-14343.
  • Spegazzini, N., Barman, I., Dingari, N. C., Pandey, R., Soares, J. S., Ozaki, Y., Dasari, R. R. (2014).  Spectroscopic approach for dynamic bioanalyte tracking with minimal concentration information.  Scientific Reports.  4(7013).
  • Valdez, T. A., Pandey, R., Spegazzini, N., Longo, K., Roehm, C., Dasari, R. R., Barman, I. (2014).  Multi-wavelength fluorescence otoscope for video-rate chemical imaging of middle ear pathology.  Analytical chemistry.  86(20).  10454-60.
  • Myakalwar, A. K., Dingari, N. C., Dasari, R. R., Barman, I., Gundawar, M. K. (2014).  Non-Gated Laser Induced Breakdown Spectroscopy Provides a Powerful Segmentation Tool on Concomitant Treatment of Characteristic and Continuum Emission.  PloS one.  9(8).  e103546.
  • Smulko, J. M., Dingari, N. C., Soares, J. S., Barman, I. (2014).  Anatomy of noise in quantitative biological Raman spectroscopy.  Bioanalysis.  6(3).  411–421.
  • Kumar, R., Singh, G. P., Barman, I., Dingari, N. C., Nabi, G. (2013).  A facile and real-time spectroscopic method for biofluid analysis in point-of-care diagnostics.  Bioanalysis.  5(15).  1853–1861.
  • Barman, I., Dingari, N. C., Saha, A., McGee, S., Galindo, L. H., Liu, W., Plecha, D., Klein, N., Dasari, R. R., Fitzmaurice, M. (2013).  Application of Raman spectroscopy to identify microcalcifications and underlying breast lesions at stereotactic core needle biopsy.  Cancer research.  73(11).  3206–3215.
  • Dingari, N. C., Barman, I., Saha, A., McGee, S., Galindo, L. H., Liu, W., Plecha, D., Klein, N., Dasari, R. R., Fitzmaurice, M. (2013).  Development and comparative assessment of Raman spectroscopic classification algorithms for lesion discrimination in stereotactic breast biopsies with microcalcifications.  Journal of biophotonics.  6(4).  371–381.
  • Soares, J. S., Barman, I., Dingari, N. C., Volynskaya, Z., Liu, W., Klein, N., Plecha, D., Dasari, R. R., Fitzmaurice, M. (2013).  Diagnostic power of diffuse reflectance spectroscopy for targeted detection of breast lesions with microcalcifications.  Proceedings of the National Academy of Sciences.  110(2).  471–476.
  • Joshi, B., Barman, I., Dingari, N. C., Cardenas, N., Soares, J. S., Dasari, R. R., Mohanty, S. (2013).  Label-free route to rapid, nanoscale characterization of cellular structure and dynamics through opaque media.  Scientific reports.  3.
  • Sathyavathi, R., Dingari, N. C., Barman, I., Prasad, P., Prabhakar, S., Narayana Rao, D., Dasari, R. R., Undamatla, J. (2013).  Raman spectroscopy provides a powerful, rapid diagnostic tool for the detection of tuberculous meningitis in ex vivo cerebrospinal fluid samples.  Journal of biophotonics.  6(8).  567–572.
  • Tan, K. M., Barman, I., Dingari, N. C., Singh, G. P., Chia, T. F., Tok, W. L. (2013).  Toward the Development of Raman Spectroscopy as a Nonperturbative Online Monitoring Tool for Gasoline Adulteration.  Analytical chemistry.  85(3).  1846–1851.
  • Dingari, N. C., Barman, I., Myakalwar, A. K., Tewari, S. P., Kumar Gundawar, M. (2012).  Incorporation of support vector machines in the LIBS toolbox for sensitive and robust classification amidst unexpected sample and system variability.  Analytical chemistry.  84(6).  2686–2694.
  • Barman, I., Dingari, N. C., Singh, G. P., Soares, J. S., Dasari, R. R., Smulko, J. M. (2012).  Investigation of noise-induced instabilities in quantitative biological spectroscopy and its implications for noninvasive glucose monitoring.  Analytical chemistry.  84(19).  8149–8156.
  • Lue, N., Kang, J. W., Yu, C., Barman, I., Dingari, N. C., Feld, M. S., Dasari, R. R., Fitzmaurice, M. (2012).  Portable optical fiber probe-based spectroscopic scanner for rapid cancer diagnosis: a new tool for intraoperative margin assessment.  PloS one.  7(1).  e30887.
  • Saha, A., Barman, I., Dingari, N. C., Galindo, L. H., Sattar, A., Liu, W., Plecha, D., Klein, N., Dasari, R. R., Fitzmaurice, M. (2012).  Precision of Raman spectroscopy measurements in detection of microcalcifications in breast needle biopsies.  Analytical chemistry.  84(15).  6715–6722.
  • Dingari, N. C., Horowitz, G. L., Kang, J. W., Dasari, R. R., Barman, I. (2012).  Raman spectroscopy provides a powerful diagnostic tool for accurate determination of albumin glycation.  PloS one.  7(2).  e32406.
  • Barman, I., Dingari, N. C., Kang, J. W., Horowitz, G. L., Dasari, R. R., Feld, M. S. (2012).  Raman spectroscopy-based sensitive and specific detection of glycated hemoglobin.  Analytical chemistry.  84(5).  2474–2482.
  • Barman, I., Dingari, N. C., Singh, G. P., Kumar, R., Lang, S., Nabi, G. (2012).  Selective sampling using confocal Raman spectroscopy provides enhanced specificity for urinary bladder cancer diagnosis.  Analytical and bioanalytical chemistry.  404(10).  3091–3099.
  • Kong, C., Barman, I., Dingari, N. C., Kang, J. W., Galindo, L., Dasari, R. R., Feld, M. S. (2011).  A novel non-imaging optics based Raman spectroscopy device for transdermal blood analyte measurement.  AIP advances.  1(3).
  • Kang, J. W., Lue, N., Kong, C., Barman, I., Dingari, N. C., Goldfless, S. J., Niles, J. C., Dasari, R. R., Feld, M. S. (2011).  Combined confocal Raman and quantitative phase microscopy system for biomedical diagnosis.  Biomedical optics express.  2(9).  2484–2492.
  • Barman, I., Kong, C., Singh, G. P., Dasari, R. R. (2011).  Effect of photobleaching on calibration model development in biological Raman spectroscopy.  Journal of biomedical optics.  16(1).  011004–011004.
  • Dingari, N. C., Barman, I., Singh, G. P., Kang, J. W., Dasari, R. R., Feld, M. S. (2011).  Investigation of the specificity of Raman spectroscopy in non-invasive blood glucose measurements.  Analytical and bioanalytical chemistry.  400(9).  2871–2880.
  • Myakalwar, A. K., Sreedhar, S., Barman, I., Dingari, N. C., Venugopal Rao, S., Prem Kiran, P., Tewari, S. P., Manoj Kumar, G. (2011).  Laser-induced breakdown spectroscopy-based investigation and classification of pharmaceutical tablets using multivariate chemometric analysis.  Talanta.  87.  53–59.
  • Saha, A., Barman, I., Dingari, N., McGee, S., Volynskaya, Z., Galindo, L., Liu, W., Plecha, D., Klein, N., Dasari, R., others. (2011).  Raman spectroscopy: a real-time tool for identifying microcalcifications during stereotactic breast core needle biopsies.  Biomedical optics express.  2(10).  2792–2803.
  • Barman, I., Dingari, N. C., Rajaram, N., Tunnell, J. W., Dasari, R. R., Feld, M. S. (2011).  Rapid and accurate determination of tissue optical properties using least-squares support vector machines.  Biomedical optics express.  2(3).  592–599.
  • Dingari, N. C., Barman, I., Kang, J. W., Kong, C., Dasari, R. R., Feld, M. S. (2011).  Wavelength selection-based nonlinear calibration for transcutaneous blood glucose sensing using Raman spectroscopy.  Journal of biomedical optics.  16(8).  087009–087009.
  • Barman, I., Kong, C., Singh, G. P., Dasari, R. R., Feld, M. S. (2010).  Accurate spectroscopic calibration for noninvasive glucose monitoring by modeling the physiological glucose dynamics.  Analytical chemistry.  82(14).  6104–6114.
  • Barman, I., Kong, C., Dingari, N. C., Dasari, R. R., Feld, M. S. (2010).  Development of robust calibration models using support vector machines for spectroscopic monitoring of blood glucose.  Analytical chemistry.  82(23).  9719–9726.
  • Barman, I., Tan, K. M., Singh, G. P. (2010).  Optical sectioning using single-plane-illumination Raman imaging.  Journal of Raman Spectroscopy.  41(10).  1099–1101.
  • Park, Y., Diez-Silva, M., Fu, D., Popescu, G., Choi, W., Barman, I., Suresh, S., Feld, M. S. (2010).  Static and dynamic light scattering of healthy and malaria-parasite invaded red blood cells.  Journal of biomedical optics.  15(2).  020506–020506.
  • Barman, I., Singh, G. P., Dasari, R. R., Feld, M. S. (2009).  Turbidity-corrected Raman spectroscopy for blood analyte detection.  Analytical chemistry.  81(11).  4233–4240.
  • Barman, I., Guha, S. K. (2006).  Analysis of a new combined stretch and pressure sensor for internal nodule palpation.  Sensors and Actuators A: Physical.  125(2).  210–216.
Book Chapters
  • Prasad, R., Pandey, R., Varma, A., Barman, I. (2016).  Polymer based nanoparticles for drug delivery systems and cancer therapeutics.  Natural Polymers for Drug Delivery.  CABI.  53-70.
Conference Proceedings
  • Wrobel, M., Siddhanta, S., Jędrzejewska-Szczerska, M., Smulko, J., Barman, I. (2017).  Surface-enhanced Raman spectroscopy for detection of drugs in whole human blood.  SPIE Conference Proceedings.
  • Pandey, R., Spegazzini, N., Barman, I., Horowitz, G., Lue, N., Galindo, L., Dasari, R. (2016).  Label-free and high-throughput sensing of glycated hemoglobin for point-of-care setting.  Lasers in Surgery and Medicine.  48(4).
  • Zhang, C., Siddhanta, S., Zheng, C., Barman, I. (2016).  Probing nanoscopic cell surface areas for rapid and label-free plasmon enhanced Raman detection.  Clinical and Translational Biophotonics, Optical Society of America.  JM3A. 53.
  • Barman, I., Dingari, N., Dasari, R., Feld, M., Kong, C., Feld, J., Feld, D., Hearn, A.  "Portable Raman Diagnostic System", 2017.
  • Barman, I., Li, M., Pomper, M., Ray, S.  "Prostate-specific Membrane Antigen Targeted Plasmon-enhanced Raman Spectroscopy Reporters for Molecular Imaging of Prostate Cancer"
  • Barman, I., Li, M.  "Multiplexed detection of circulating breast tumor antigen and epigenetic markers using plasmon-enhanced Raman spectroscopic assay"
  • Barman, I., Spegazzini, N., Dingari, N., Soares, J., Ozaki, Y., Dasari, R.  "Single Prick Method for the Detection of Blood Analytes", 2016.
  • Barman, I.  "Method and apparatus for permeating flow desalination", 2014.
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