Mechanical Engineering Fall Seminar Series: Class 530.803

October 19, 2017 @ 3:00 pm – 4:00 pm
210 Hodson Hall

“Dynamic traction forces exerted on the extracellular matrix mediate cellular response to microenvironment stiffness”

Presented by Professor Sergey Plotnikov
Department of Cell & Systems Biology, University of Toronto

I will be presenting our recent work on how adherent cells probe stiffness of their microenvironment through integrin-based focal adhesions. Particularly, we have been employing live cell imaging, traction forces microscopy, and mathematical modeling to understand dynamics of cellular forces exerted on the extracellular matrix. I will focus my talk on an intriguing discovery we made of how two functionally distinct cytoskeletal domains contribute to cell mechanosensing by driving calcium influx at the focal adhesions.

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