Mechanical Engineering Fall Seminar Series: Class 530.803
“Dynamic traction forces exerted on the extracellular matrix mediate cellular response to microenvironment stiffness”
Presented by Professor Sergey Plotnikov
Department of Cell & Systems Biology, University of Toronto
I will be presenting our recent work on how adherent cells probe stiffness of their microenvironment through integrin-based focal adhesions. Particularly, we have been employing live cell imaging, traction forces microscopy, and mathematical modeling to understand dynamics of cellular forces exerted on the extracellular matrix. I will focus my talk on an intriguing discovery we made of how two functionally distinct cytoskeletal domains contribute to cell mechanosensing by driving calcium influx at the focal adhesions.