BioSensing and BioMEMS 530.672

Instructor:

Prof. Tza-Huei (Jeff) Wang

Class taught:

Tue and Thur, 10:30-11:45 am, Hodson 301 

Office:

118B Clark

Office number:

410-516-7086

Email:

thwang@jhu.edu

TA Email:

Divya Nalayanda dnalaya1@jhmi.edu

Syllabus

 

Prerequisites:

Graduate students in engineering and physical science or senior undergraduate students

Textbook:

There is no textbook. The lecturing is mainly based on the notes, selected research articles of journals, and sections from the following references. The lecture notes and supplementary materials will be posted on the webpage.

References:

1. Manz and H. Becker, Microsystem Technology in Chemistry and Life Science

2.  R. Eggins, Chemical Sensors and Biosensors

3.  T. A. Kovacs, Micromachined Transducers Sourcebook

4.  M. Mardou, Fundamentals of Microfabrication

5.      Oosterbroek and van den Berg, Lab-on-a-chip Miniaturized Systems for (Bio)Chemical Analysis and Synthesis

Grading:

Homework 40 %,  Midterm exam 25 %, Labs 10%,  Project presentations 10%, Final report 10%, Class activities 5%

Homework:

Homework will be due one week after it has been given, except when otherwise advised. Homework must be submitted at the beginning of the class on the day it is due. Late submissions will be penalized 10 % for every day it is late up to one week. After one week, homework will not be accepted.

HW1:   

HW2:

HW3:

Midterm:

Due: 2/18     

Due: 3/29     

Due: 4/26     

April 14, 2016

Labs:

 

 

Term Project: 

Report

Lab I: Microfluidics, March 29 & 31  (meet in Clark 123 at 10:30am)

Lab I handout

Term Project Requirement

May 13

                           Topics:

Lecture notes

Reading Material

1. Introduction to BioMEMS

BioMEMS Introduction

Lab-on-a-chip

2. Scaling laws

Scaling I Scaling II

Feynman Scaling

3. Microfabrication process

Microfabrication I

Microfabrication II

Microfabrication

4. Polymer-based microfabrication

Soft-Lithography

Soft Lithography

5. Fluidics basics

Fluids

Microfluidics

6. Microfluidic control & measurement

Microfluidic Control I

Microfluidic Control II

Microfluidics-Ho

Molecular Manipulation

7. Forces and fields at the microscale

Force & Field

Electrokinetics-I

Electrokinetics-II

8.      Lab-on-chip systems

Lab-on-a-chip

 

9. Single-Molecule detection

10.  Micro/Nano biosensors