Journal Publications | Patents | Conference Publications

Journal Publications

152 entries « 3 of 8 »
41. Zhang, Y; Chen, L; Hsieh, K; Wang, T H: Ratiometric Fluorescence Coding for Multiplex Nucleic Acid Amplification Testing. In: Anal Chem, 90 (20), pp. 12180-12186, 2018, ISSN: 1520-6882 (Electronic) 0003-2700 (Linking). (Type: Journal Article | Abstract | Links | BibTeX)
42. Andini, N; Hu, A; Zhou, L; Cogill, S; Wang, T H; Wittwer, C T; Yang, S: A "Culture" Shift: Broad Bacterial Detection, Identification, and Antimicrobial Susceptibility Testing Directly from Whole Blood. In: Clin Chem, 64 (10), pp. 1453-1462, 2018, ISSN: 1530-8561 (Electronic) 0009-9147 (Linking). (Type: Journal Article | Abstract | Links | BibTeX)
43. Chen, L; Shin, D J; Zheng, S; Melendez, J H; Gaydos, C A; Wang, T H: Direct-qPCR Assay for Coupled Identification and Antimicrobial Susceptibility Testing of Neisseria gonorrhoeae. In: ACS Infect Dis, 4 (9), pp. 1377-1384, 2018, ISSN: 2373-8227 (Electronic) 2373-8227 (Linking). (Type: Journal Article | Abstract | Links | BibTeX)
44. O'Keefe, C M; Pisanic, 2nd T R; Zec, H; Overman, M J; Herman, J G; Wang, T H: Facile profiling of molecular heterogeneity by microfluidic digital melt. In: Sci Adv, 4 (9), pp. eaat6459, 2018, ISSN: 2375-2548 (Electronic) 2375-2548 (Linking). (Type: Journal Article | Abstract | Links | BibTeX)
45. Hsieh, K; Zec, H C; Chen, L; Kaushik, A M; Mach, K E; Liao, J C; Wang, T H: Simple and Precise Counting of Viable Bacteria by Resazurin-Amplified Picoarray Detection. In: Anal Chem, 90 (15), pp. 9449-9456, 2018, ISSN: 1520-6882 (Electronic) 0003-2700 (Linking). (Type: Journal Article | Abstract | Links | BibTeX)
46. Surrette, C; Scherer, B; Corwin, A; Grossmann, G; Kaushik, A M; Hsieh, K; Zhang, P; Liao, J C; Wong, P K; Wang, T H; Puleo, C M: Rapid Microbiology Screening in Pharmaceutical Workflows. In: SLAS Technol, 23 (4), pp. 387-394, 2018, ISSN: 2472-6311 (Electronic) 2472-6303 (Linking). (Type: Journal Article | Abstract | Links | BibTeX)
47. Song, Jian; Dailey, Jennifer; Li, Hui; Jang, Hyun-June; Russell, Luisa; Zhang, Pengfei; Searson, Peter C; Wang, Jeff Tza-Huei; Everett, Allen D; Katz, Howard E: Influence of Bioreceptor Layer Structure on Myelin Basic Protein Detection using Organic Field Effect Transistor-Based Biosensors. In: Advanced Functional Materials, 28 (37), pp. 1802605, 2018, ISSN: 1616301X. (Type: Journal Article | Abstract | Links | BibTeX)
48. Shin, D J; Trick, A Y; Hsieh, Y H; Thomas, D L; Wang, T H: Sample-to-Answer Droplet Magnetofluidic Platform for Point-of-Care Hepatitis C Viral Load Quantitation. In: Sci Rep, 8 (1), pp. 9793, 2018, ISSN: 2045-2322 (Electronic) 2045-2322 (Linking). (Type: Journal Article | Abstract | Links | BibTeX)
49. Shin, D J; Lewis, M; Hsieh, Y H; Rahmoun, N A; Gaydos, C A; Wang, T H; Rothman, R: Healthcare worker feedback on a prototype smartphone-based point-of-care test platform for use in episodic care. In: Point Care, 17 (2), pp. 63-65, 2018, ISSN: 1533-029X (Print) 1533-029X (Linking). (Type: Journal Article | Abstract | Links | BibTeX)
50. Stark, A; Shin, D J; Wang, T H: A sample-to-answer droplet magnetofluidic assay platform for quantitative methylation-specific PCR. In: Biomed Microdevices, 20 (2), pp. 31, 2018, ISSN: 1572-8781 (Electronic) 1387-2176 (Linking). (Type: Journal Article | Abstract | Links | BibTeX)
51. Zec, Helena C; Zheng, Tony; Liu, Lingshu; Hsieh, Kuangwen; Rane, Tushar D; Pederson, Todd; Wang, Tza-Huei: Programmable microfluidic genotyping of plant DNA samples for marker-assisted selection. In: Microsystems & Nanoengineering, 4 , pp. 17097, 2018, ISSN: 2055-7434. (Type: Journal Article | Abstract | Links | BibTeX)
52. Kaushik, A M; Hsieh, K; Chen, L; Shin, D J; Liao, J C; Wang, T H: Accelerating bacterial growth detection and antimicrobial susceptibility assessment in integrated picoliter droplet platform. In: Biosens Bioelectron, 97 , pp. 260-266, 2017, ISSN: 1873-4235 (Electronic) 0956-5663 (Linking). (Type: Journal Article | Abstract | Links | BibTeX)
53. Kilburn, D; Song, Y; Wang, T H; Liu, K J: A Multiplex Ligation Assay for miRNA Copy Number Profiling. In: Methods Mol Biol, 1509 , pp. 185-193, 2017, ISSN: 1940-6029 (Electronic) 1064-3745 (Linking). (Type: Journal Article | Abstract | Links | BibTeX)
54. Athamanolap, P; Hsieh, K; Chen, L; Yang, S; Wang, T H: Integrated Bacterial Identification and Antimicrobial Susceptibility Testing Using PCR and High-Resolution Melt. In: Anal Chem, 89 (21), pp. 11529-11536, 2017, ISSN: 1520-6882 (Electronic) 0003-2700 (Linking). (Type: Journal Article | Abstract | Links | BibTeX)
55. Friedrich, S M; Burke, J M; Liu, K J; Ivory, C F; Wang, T H: Molecular rheotaxis directs DNA migration and concentration against a pressure-driven flow. In: Nat Commun, 8 (1), pp. 1213, 2017, ISSN: 2041-1723 (Electronic) 2041-1723 (Linking). (Type: Journal Article | Abstract | Links | BibTeX)
56. Axt, B; Hsieh, Y F; Nalayanda, D; Wang, T H: Impedance feedback control of microfluidic valves for reliable post processing combinatorial droplet injection. In: Biomed Microdevices, 19 (3), pp. 61, 2017, ISSN: 1572-8781 (Electronic) 1387-2176 (Linking). (Type: Journal Article | Abstract | Links | BibTeX)
57. Song, Y; Kilburn, D; Song, J H; Cheng, Y; Saeui, C T; Cheung, D G; Croce, C M; Yarema, K J; Meltzer, S J; Liu, K J; Wang, T H: Determination of absolute expression profiles using multiplexed miRNA analysis. In: PLoS One, 12 (7), pp. e0180988, 2017, ISSN: 1932-6203 (Electronic) 1932-6203 (Linking). (Type: Journal Article | Abstract | Links | BibTeX)
58. Shin, D J; Athamanolap, P; Chen, L; Hardick, J; Lewis, M; Hsieh, Y H; Rothman, R E; Gaydos, C A; Wang, T H: Mobile nucleic acid amplification testing (mobiNAAT) for Chlamydia trachomatis screening in hospital emergency department settings. In: Sci Rep, 7 (1), pp. 4495, 2017, ISSN: 2045-2322 (Electronic) 2045-2322 (Linking). (Type: Journal Article | Abstract | Links | BibTeX)
59. Davenport, M; Mach, K E; Shortliffe, L M D; Banaei, N; Wang, T H; Liao, J C: New and developing diagnostic technologies for urinary tract infections. In: Nat Rev Urol, 14 (5), pp. 296-310, 2017, ISSN: 1759-4820 (Electronic) 1759-4812 (Linking). (Type: Journal Article | Abstract | Links | BibTeX)
60. Hulbert, A; Jusue-Torres, I; Stark, A; Chen, C; Rodgers, K; Lee, B; Griffin, C; Yang, A; Huang, P; Wrangle, J; Belinsky, S A; Wang, T H; Yang, S C; Baylin, S B; Brock, M V; Herman, J G: Early Detection of Lung Cancer Using DNA Promoter Hypermethylation in Plasma and Sputum. In: Clin Cancer Res, 23 (8), pp. 1998-2005, 2017, ISSN: 1078-0432 (Print) 1078-0432 (Linking). (Type: Journal Article | Abstract | Links | BibTeX)
152 entries « 3 of 8 »

152 entries « 3 of 4 »

2014

D. J. Shin; T. H. Wang

Magnetic droplet manipulation platforms for nucleic acid detection at the point of care Journal Article

Ann Biomed Eng, 42 (11), pp. 2289-302, 2014, ISSN: 1573-9686 (Electronic) 0090-6964 (Linking).

Abstract | Links | BibTeX

P. Athamanolap; V. Parekh; S. I. Fraley; V. Agarwal; D. J. Shin; M. A. Jacobs; T. H. Wang; S. Yang

Trainable high resolution melt curve machine learning classifier for large-scale reliable genotyping of sequence variants Journal Article

PLoS One, 9 (9), pp. e109094, 2014, ISSN: 1932-6203 (Electronic) 1932-6203 (Linking).

Abstract | Links | BibTeX

A. A. Guzzetta; T. R. Pisanic Ii; P. Sharma; J. M. Yi; A. Stark; T. H. Wang; N. Ahuja

The promise of methylation on beads for cancer detection and treatment Journal Article

Expert Rev Mol Diagn, 14 (7), pp. 845-52, 2014, ISSN: 1744-8352 (Electronic) 1473-7159 (Linking).

Abstract | Links | BibTeX

H. Zec; D. J. Shin; T. H. Wang

Novel droplet platforms for the detection of disease biomarkers Journal Article

Expert Rev Mol Diagn, 14 (7), pp. 787-801, 2014, ISSN: 1744-8352 (Electronic) 1473-7159 (Linking).

Abstract | Links | BibTeX

C. W. Beh; D. Pan; J. Lee; X. Jiang; K. J. Liu; H. Q. Mao; T. H. Wang

Direct interrogation of DNA content distribution in nanoparticles by a novel microfluidics-based single-particle analysis Journal Article

Nano Lett, 14 (8), pp. 4729-35, 2014, ISSN: 1530-6992 (Electronic) 1530-6984 (Linking).

Abstract | Links | BibTeX

D. J. Shin; Y. Zhang; T. H. Wang

A droplet microfluidic approach to single-stream nucleic acid isolation and mutation detection Journal Article

Microfluid Nanofluidics, 17 (2), pp. 425-430, 2014, ISSN: 1613-4982 (Print) 1613-4982 (Linking).

Abstract | Links | BibTeX

T. R. 2nd Pisanic; Y. Zhang; T. H. Wang

Quantum dots in diagnostics and detection: principles and paradigms Journal Article

Analyst, 139 (12), pp. 2968-81, 2014, ISSN: 1364-5528 (Electronic) 0003-2654 (Linking).

Abstract | Links | BibTeX

P. Athamanolap; D. J. Shin; T. H. Wang

Droplet Array Platform for High-Resolution Melt Analysis of DNA Methylation Density Journal Article

J Lab Autom, 19 (3), pp. 304-12, 2014, ISSN: 2211-0690 (Electronic) 2211-0682 (Linking).

Abstract | Links | BibTeX

Y. Song; K. J. Liu; T. H. Wang

Elimination of ligation dependent artifacts in T4 RNA ligase to achieve high efficiency and low bias microRNA capture Journal Article

PLoS One, 9 (4), pp. e94619, 2014, ISSN: 1932-6203 (Electronic) 1932-6203 (Linking).

Abstract | Links | BibTeX

L. Zhang; Y. Song; T. Fujita; Y. Zhang; M. Chen; T. H. Wang

Large enhancement of quantum dot fluorescence by highly scalable nanoporous gold Journal Article

Adv Mater, 26 (8), pp. 1289-94, 2014, ISSN: 1521-4095 (Electronic) 0935-9648 (Linking).

Abstract | Links | BibTeX

D. D. Nalayanda; W. B. Fulton; P. M. Colombani; T. H. Wang; F. Abdullah

Pressure induced lung injury in a novel in vitro model of the alveolar interface: protective effect of dexamethasone Journal Article

J Pediatr Surg, 49 (1), pp. 61-5; discussion 65, 2014, ISSN: 1531-5037 (Electronic) 0022-3468 (Linking).

Abstract | Links | BibTeX

2013

Y. Zhang; D. J. Shin; T. H. Wang

Serial dilution via surface energy trap-assisted magnetic droplet manipulation Journal Article

Lab Chip, 13 (24), pp. 4827-31, 2013, ISSN: 1473-0189 (Electronic) 1473-0189 (Linking).

Abstract | Links | BibTeX

C. H. Chiou; D. J. Shin; Y. Zhang; T. H. Wang

Topography-assisted electromagnetic platform for blood-to-PCR in a droplet Journal Article

Biosens Bioelectron, 50 , pp. 91-9, 2013, ISSN: 1873-4235 (Electronic) 0956-5663 (Linking).

Abstract | Links | BibTeX

J. M. Yi; A. A. Guzzetta; V. J. Bailey; S. R. Downing; L. Van Neste; K. B. Chiappinelli; B. P. Keeley; A. Stark; A. Herrera; C. Wolfgang; E. P. Pappou; C. A. Iacobuzio-Donahue; M. G. Goggins; J. G. Herman; T. H. Wang; S. B. Baylin; N. Ahuja

Novel methylation biomarker panel for the early detection of pancreatic cancer Journal Article

Clin Cancer Res, 19 (23), pp. 6544-6555, 2013, ISSN: 1078-0432 (Print) 1078-0432 (Linking).

Abstract | Links | BibTeX

B. Keeley; A. Stark; T. R. 2nd Pisanic; R. Kwak; Y. Zhang; J. Wrangle; S. Baylin; J. Herman; N. Ahuja; M. V. Brock; T. H. Wang

Extraction and processing of circulating DNA from large sample volumes using methylation on beads for the detection of rare epigenetic events Journal Article

Clin Chim Acta, 425 , pp. 169-75, 2013, ISSN: 1873-3492 (Electronic) 0009-8981 (Linking).

Abstract | Links | BibTeX

S. I. Fraley; J. Hardick; B. J. Masek; P. Athamanolap; R. E. Rothman; C. A. Gaydos; K. C. Carroll; T. Wakefield; T. H. Wang; S. Yang

Universal digital high-resolution melt: a novel approach to broad-based profiling of heterogeneous biological samples Journal Article

Nucleic Acids Res, 41 (18), pp. e175, 2013, ISSN: 1362-4962 (Electronic) 0305-1048 (Linking).

Abstract | Links | BibTeX

D. D. Nalayanda; W. B. Fulton; T. H. Wang; F. Abdullah

A multiphase fluidic platform for studying ventilator-induced injury of the pulmonary epithelial barrier Journal Article

Integr Biol (Camb), 5 (9), pp. 1141-8, 2013, ISSN: 1757-9708 (Electronic) 1757-9694 (Linking).

Abstract | Links | BibTeX

T. H. Wang

Micro and nanotechnologies enhanced biomolecular sensing Journal Article

Biosensors (Basel), 3 (3), pp. 283-5, 2013, ISSN: 2079-6374 (Print) 2079-6374 (Linking).

Abstract | Links | BibTeX

Y. Zhang; T. H. Wang

Full-range magnetic manipulation of droplets via surface energy traps enables complex bioassays Journal Article

Adv Mater, 25 (21), pp. 2903-8, 2013, ISSN: 1521-4095 (Electronic) 0935-9648 (Linking).

Abstract | Links | BibTeX

Y. Song; Y. Zhang; T. H. Wang

Single quantum dot analysis enables multiplexed point mutation detection by gap ligase chain reaction Journal Article

Small, 9 (7), pp. 1096-105, 2013, ISSN: 1613-6829 (Electronic) 1613-6810 (Linking).

Abstract | Links | BibTeX

T. H. Wang

Discerning single molecule interactions of DNA and quantum dots Journal Article

Biotechnol J, 8 (1), pp. 15-6, 2013, ISSN: 1860-7314 (Electronic) 1860-6768 (Linking).

Abstract | Links | BibTeX

2012

C. W. Beh; W. Zhou; T. H. Wang

PDMS-glass bonding using grafted polymeric adhesive--alternative process flow for compatibility with patterned biological molecules Journal Article

Lab Chip, 12 (20), pp. 4120-7, 2012, ISSN: 1473-0189 (Electronic) 1473-0189 (Linking).

Abstract | Links | BibTeX

T. D. Rane; H. C. Zec; T. H. Wang

A serial sample loading system: interfacing multiwell plates with microfluidic devices Journal Article

J Lab Autom, 17 (5), pp. 370-7, 2012, ISSN: 2211-0690 (Electronic) 2211-0682 (Linking).

Abstract | Links | BibTeX

T. D. Rane; H. C. Zec; C. Puleo; A. P. Lee; T. H. Wang

Droplet microfluidics for amplification-free genetic detection of single cells Journal Article

Lab Chip, 12 (18), pp. 3341-7, 2012, ISSN: 1473-0189 (Electronic) 1473-0189 (Linking).

Abstract | Links | BibTeX

H. Zec; T. D. Rane; T. H. Wang

Microfluidic platform for on-demand generation of spatially indexed combinatorial droplets Journal Article

Lab Chip, 12 (17), pp. 3055-62, 2012, ISSN: 1473-0189 (Electronic) 1473-0189 (Linking).

Abstract | Links | BibTeX

Y. Zhang; T. H. Wang

Quantum dot enabled molecular sensing and diagnostics Journal Article

Theranostics, 2 (7), pp. 631-54, 2012, ISSN: 1838-7640 (Electronic) 1838-7640 (Linking).

Abstract | Links | BibTeX

Y. Zhang; T. H. Wang

Micro Magnetic Gyromixer for Speeding up Reactions in Droplets Journal Article

Microfluid Nanofluidics, 12 (5), pp. 787-794, 2012, ISSN: 1613-4982 (Print) 1613-4982 (Linking).

Abstract | Links | BibTeX

Y. Zhang; K. J. Liu; T. L. Wang; M. Shih Ie; T. H. Wang

Mapping DNA quantity into electrophoretic mobility through quantum dot nanotethers for high-resolution genetic and epigenetic analysis Journal Article

ACS Nano, 6 (1), pp. 858-64, 2012, ISSN: 1936-086X (Electronic) 1936-0851 (Linking).

Abstract | Links | BibTeX

2011

S. Park; Y. Zhang; S. Lin; T. H. Wang; S. Yang

Advances in microfluidic PCR for point-of-care infectious disease diagnostics Journal Article

Biotechnol Adv, 29 (6), pp. 830-9, 2011, ISSN: 1873-1899 (Electronic) 0734-9750 (Linking).

Abstract | Links | BibTeX

S. Park; Y. Zhang; T. H. Wang; S. Yang

Continuous dielectrophoretic bacterial separation and concentration from physiological media of high conductivity Journal Article

Lab Chip, 11 (17), pp. 2893-900, 2011, ISSN: 1473-0189 (Electronic) 1473-0189 (Linking).

Abstract | Links | BibTeX

Yi Zhang; Tza-Huei Wang

Quantum Dots-Enabled High-Resolution Analysis of Gene Copy Number Variation Journal Article

IEEE Nanotechnology Magazine, 5 (2), pp. 23-27, 2011, ISSN: 1932-4510.

Links | BibTeX

K. J. Liu; T. D. Rane; Y. Zhang; T. H. Wang

Single-molecule analysis enables free solution hydrodynamic separation using yoctomole levels of DNA Journal Article

J Am Chem Soc, 133 (18), pp. 6898-901, 2011, ISSN: 1520-5126 (Electronic) 0002-7863 (Linking).

Abstract | Links | BibTeX

Y. Zhang; S. Park; K. Liu; J. Tsuan; S. Yang; T. H. Wang

A surface topography assisted droplet manipulation platform for biomarker detection and pathogen identification Journal Article

Lab Chip, 11 (3), pp. 398-406, 2011, ISSN: 1473-0189 (Electronic) 1473-0189 (Linking).

Abstract | Links | BibTeX

2010

Y. Zhang; S. Park; S. Yang; T. H. Wang

An all-in-one microfluidic device for parallel DNA extraction and gene analysis Journal Article

Biomed Microdevices, 12 (6), pp. 1043-9, 2010, ISSN: 1572-8781 (Electronic) 1387-2176 (Linking).

Abstract | Links | BibTeX

V. J. Bailey; B. P. Keeley; C. R. Razavi; E. Griffiths; H. E. Carraway; T. H. Wang

DNA methylation detection using MS-qFRET, a quantum dot-based nanoassay Journal Article

Methods, 52 (3), pp. 237-41, 2010, ISSN: 1095-9130 (Electronic) 1046-2023 (Linking).

Abstract | Links | BibTeX

T. H. Wang; V.J. Bailey; Y. Zhang; K. J. Liu

Quantum Dots DNA Nanosensors - Ultrasensitive Platform for Detecting Genomic Cancer Markers Journal Article

BIOforum Europe, 1-2:28-30, 2010.

BibTeX

X. Jiang; Y. Zheng; H. H. Chen; K. W. Leong; T. H. Wang; H. Q. Mao

Dual-sensitive micellar nanoparticles regulate DNA unpacking and enhance gene-delivery efficiency Journal Article

Adv Mater, 22 (23), pp. 2556-60, 2010, ISSN: 1521-4095 (Electronic) 0935-9648 (Linking).

Links | BibTeX

Tza-Huei Wang; Pak Kin Wong

Transforming Microfluidics into Laboratory Automation Journal Article

Journal of the Association for Laboratory Automation, 15 (3), pp. A15-A16, 2010, ISSN: 15355535.

Links | BibTeX

V. J. Bailey; Y. Zhang; B. P. Keeley; C. Yin; K. L. Pelosky; M. Brock; S. B. Baylin; J. G. Herman; T. H. Wang

Single-tube analysis of DNA methylation with silica superparamagnetic beads Journal Article

Clin Chem, 56 (6), pp. 1022-5, 2010, ISSN: 1530-8561 (Electronic) 0009-9147 (Linking).

Abstract | Links | BibTeX

K. J. Liu; M. V. Brock; M. Shih Ie; T. H. Wang

Decoding circulating nucleic acids in human serum using microfluidic single molecule spectroscopy Journal Article

J Am Chem Soc, 132 (16), pp. 5793-8, 2010, ISSN: 1520-5126 (Electronic) 0002-7863 (Linking).

Abstract | Links | BibTeX

152 entries « 3 of 4 »

Top

Patents

  1. H. Wang, F.M. Friedrich, J.M. Burke, and K. Liu “Concentration and Accumulation of Target Species in Response to a Gradient of Solute or Solvent” (JHU Ref. C13791; US provisional patent)
  2. H. Wang, K. Hsieh, H. Zec, L. Liu, A.M. Kaushik, Y. Yun, “Multiplexed, Continuous-flow, droplet-based platform for high-throughput genetic detection” (JHU Ref. C13529; US provisional patent)
  3. H. Wang, T.D. Rane, H.C Zec, “System and device for high throughput generation of combinatorial droplets and methods of use”  (PCT/US2015/012927; JHU Ref. C12862)
  4. H. Wang, D.J. Shin, “Self-contained cartridge and methods for integrated biochemical assay at the point-of-care” (JHU Ref. C12720)
  5. -H. Wang, S. Yang, M.A. Jacobs, P. Athamanolap, S.I. Fraley, V. Agarwal, V. Parekh. “Melt curve classifier for reliable large-scale genotyping of sequence variants” JHU Case Number C12600, provisional patent
  6. Stephanie I. Fraley, T.-H. Wang, and S. Yang. “A novel technology for broad-based, yet single molecule sensitive profiling in heterogeneous biological samples.” JHU Case Number C12403, provisional patent
  7. H. Wang, Y. Zhang, “Fabrication of Hierarchical Silica Nanomembrane using Heat-Shrinking Polymers and Applications of Silica Nanomembrane for the Solid Phase Extraction of Nucleic Acids”, JHU Case Number C12404, provisional patent
  8. H. Wang, Chi-Hang Chiou, Dong Jin Shin , “Electromagnetically Actuated Droplet Microfluidic Chip and System” (JHU Ref. C12262)
  9. H. Wang and Y. Zhang, “Surface Energy Traps (SETs) Enabled Complex Droplet Manipulation” (JHU Ref. C11971)
  10. H. Wang, K. Liu and Y. Song, “miRNA Analysis Method” (US Provisional US 61/598513, JHU Ref. C11885)
  11. H. Wang, T.D. Rane, H. C. Zec and W.Ch. Chu “Systems and methods for screening a library of samples” (US13/708,510. JHU Ref. C11803)
  12. Yang, T.H. Wang, S.K. Park and Y Zhang, “Method and apparatus for continuous microfluidic sample separation and concentration using AC electric field” (JHU Ref. C11562)
  13. H. Wang, Y. Zhang, S. Park and S. Yang, “Self-sustained Droplet Microfluidic Chip and System for Integrated Sample Preparation and Nucleic Acids Detection” (PCT/US2011/045363, JHU Ref. C11183)
  14. H. Wang, H.Q. Mao, W. Beh and D. Kraitchman, “Kilohertz Generation of Monodisperse Microbeads on a Polymeric Membrane Microfluidic Pseudocheck Valve Device” (PCT/US2011/054598, JHU Ref. C11248)
  15. Ahuja, V. Bailey, S.B. Baylin, J.G. Herman, T.H. Wang, J. Yi, “Early Detection of DNA Methylation Biomarker in Cancer Patient Sera” (PCT/US2011/037926, JHU Ref. C11091)
  16. H. Wang and K. Liu, “Hydrodynamic Particle Separation and Detection Systems and Methods”, (PCT/US2011/056941, JHU Ref. C11263)
  17. H. Wang and K.J. Liu, “Single Molecule Spectroscopy for Analysis of Cell-free Nucleic Acid Biomarkers” (PCT/US2010/033888, JHU Ref. C10750)
  18. H. Wang and Y. Zhang, ” Device and Method of Preparing and Performing Multiple Polymerase Chain Reactions” (US 12/716,031, JHU Ref. C10659)
  19. H. Wang, S. Baylin, J. Herman, H. Easwaran and H. Carraway, “Compositions and Methods for Polynucleotide Extraction and Methylation Detection” (PCT/US2009/000039, JHU Ref. C10249)
  20. M. Ho and T.H. Wang, “Biosensors and Methods for Their Use” (PCT/US2001/025444)
  21. H. Wang, K.J. Liu, and I.M. Shih, ” DNA Integrity Assay (DIA) for Cancer Diagnostics, Using Confocal Fluorescence Spectroscopy” (US8,835,110, JHU Ref. C10534)
  22. H. Wang and K. Liu, “Cylindrical Illumination Confocal Spectroscopy System” (US8,248,609, JHU Ref. C10398)
  23. H. Wang, K.J. Liu, C.M. Puleo and T. Rane, ” Microfluidic System for High-Throughput, Droplet-based, Single Molecule Analysis with Low Reagent Consumption” (US9,284,601, issued on 03/15/2016, JHU Ref. C10662)
  24. F. Miller, J. Huang, T.H. Wang, C.M. Ho and M. Liu, “Electrochemical Detection of Mismatch in Nucleic Acids” (US 7,291,457)
  25. H. Wang, “Method for determining standard cycle time of a stage dynamically” (US5,825,650)
  26. A. Hulbert, J. Herman, M. Brock, T.H. Wang, and A. Stark “Early detection of Individuals at High Risk for Lung Cancer of all Stages Using Gene promoter Methylation in Plasma and Sputum” JHU C13599

Top

Conference Publications

  1. J. Shin, P. Athamanolap, L.Chen, J. Hardick, CA Gaydos and T.H. Wang, “A Smartphone-Based Mobile NAAT Diagnostic Suite for Chlamydia Detection”, Proc. 26th Anniversary World Congress on Biosensors (Biosensors 2016), (accepted)
  2. M. Friedrich, J.M. Burke, K.J. Liu, T.H. Wang, “In-line Preconcentration, Size Separation, and Single-Molecule Detection Without Applied Electric Fields, Proc. 29th IEEE International Conference on Micro Electro Mechanical Systems (IEEE MEMS 2016), p. 181-184, 2016
  3. J. Shin, L. Chen and T.H. Wang, “Single-bacteria Confocal Spectroscopy: An Ultrasensitive method for Real-time Monitoring of Bacterial Growth”, Proc. 19th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (micro-TAS 2015), p. 340-342, 2015
  4. Kaushik, K. Hsieh, L. Chen, D.J. Shin and T.H. Wang, “Rapid Assessment of Bacterial Vitality and Antibiotic Susceptibility via High-Throughput Picoliter-Droplet Single-Cell Assay”, Proc. 19th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (micro-TAS 2015), p. 531-533, 2015
  5. Liu, K. Hsieh, A. Kaushik, H.C. Zec and T.H. Wang, “Multiplexed, Continuous-Flow, Droplet-Based PCR Genotyping Platform for High-Throughput Agriculture Marker Assisted Selection”, Proc. 19th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (micro-TAS 2015), p. 1368-1370, 2015
  6. Zec, C. O’Keefe, P. Ma, T.H. Wang, “Ultra-Thin, Evaporation-Resistant PDMS Devices for Absolute Quantification of DNA Using Digital PCR”, The 18th International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers 2015), p.536-539, 2015
  7. Guan, L. Chen, T. Rane, A. Kaushik, T.H. Wang, “Digital Droplet ELOHA For Nucleic Molecule Counting And Analysis”, The 18th International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers 2015), p.536-5460-463, 2015
  8. C. Zec, C.J. Glover, W. Hsieh, L. Liu, C. O’Keefe and T.H. Wang, “Methods for Controlling Water Evaporation in PDMS-Based Microfluidic Devices”, Proc. 18th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (micro-TAS 2014), p. 1743-1745, 2014
  9. J. Shin, P. Athamanonolap, L. Chen and T.H. Wang, “Integrated droplet microfluidic platform for nucleic acids amplification test of Chlamydia trachomatis infection”, Proc. 24th Anniversary World Congress on Biosensors (Biosensors 2014)
  10. C. Zec, T.D. Rane, P. Ma and T.H. Wang, “Parallelization of Fission and Fusion- Operations for High Throughput Generation of Combinatorial Droplets”, Proc. 27th IEEE International Conference on Micro Electro Mechanical Systems (IEEE MEMS 2014), p. 334-337, 2014
  11. J. Shin, L. Chen and T.H. Wang, “A Simple Integrated Diagnostic Platform for DNA Testing of Chlamydia Trachomatis Infection, “ Proc. 17th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (micro-TAS 2013), p. 1350-1352, 2013
  12. M. Friedrich, K.J. Liu and T.H. Wang, “ Single Molecule Hydrodynamic Separation for Ultrasensitive and Quantitative DNA Size Separations,” Proc. 17th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (micro-TAS 2013), p. 35-37, 2013
  13. D. Rane, H.C. Zec and T.H. Wang, “A Multiplexed Microfluidic Droplet Platform for Matrix Metalloproteinase Screening”, Proc. 17th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (micro-TAS 2013), p. 1595-1597, 2013
  14. K. Wu, S. F. Friedrich, K.J. Liu and T.H. Wang, “ Chip-Based DNA Separation in Free Solution by Inertial Hydrodynamic Forces”, Proc. 17th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (micro-TAS 2013), p. 578-580, 2013
  15. J. Shin, A. Stark and T.H. Wang, “ Droplet Bisulfite Conversion Platform for Epigenetic Cancer Biomarker Detection”, The 17th International Conference on Solid-State Sensors, Actuators and Microsystems(Transducers 2013), p.2181-2184, 2013
  16. Zhang, Y. Zhang, B. Keeley, A. Stark and T.H. Wang, “Spontaneous Shrinking Silica Nanomembrane for Solid Phase”, Proc. 8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems (IEEE NEMS 2013), p. 444-445, 2013
  17. Athamanolap, B. Keeley, D.J. Shin and T.H. Wang, “Quantitative Analysis of DNA Methylation Based on Melting Curve Analysis”, Proc. 8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems (IEEE NEMS 2013), p.1116-1118, 2013
  18. Zhang, Y Zhang, T.H. Wang, “Hierarchical Silica Nanomembrane Driven by Thermal Shrinkage and its Application for Solid Phase DNA Extraction”, Proc. The 13th IEEE International Conference on Nanotechnology (IEEE NANO 2013), 2013
  19. C. Zec, T.D. Rane, W.C. Chu, V. Wang and T.H. Wang, “ A Microfluidic Droplet Platform for Multiplexed Single Nucleotide Polymorphism Analysis of an Array Plant Genomic DNA Samples”, Proc. 26th IEEE International Conference on Micro Electro Mechanical Systems (IEEE MEMS 2013), p.263-266, 2013
  20. H. Chiou, D.J. Shin, S. Hosmane, Y Zhang and T.H. Wang, “Electromagnet-Actuated Droplet Platform for Sample-to-Answer Genetic Detection”, Proc. 26th IEEE International Conference on Micro Electro Mechanical Systems (IEEE MEMS 2013), p.98-101, 2013
  21. Zhang and T.H. Wang, “ All-in-One Droplet Platform for Multiplexed Genetic Detection in Blood” Proc. 26th IEEE International Conference on Micro Electro Mechanical Systems (IEEE MEMS 2013), p. 1061-1064, 2013
  22. Zhang and T.H. Wang, “Flip-Drop: Droplet Array Created by Surface Energy Trap for Combinatorial Screening,” Proc. 26th IEEE International Conference on Micro Electro Mechanical Systems (IEEE MEMS 2013), p.1149-1152, 2013
  23. W. Beh, C. Weiss, H.Q. Mao, D. L. Kraitchman, and T.H. Wang, “High-Throughput Microfluidic Preparation of Imaging-Visible Embolic Beads”, Proc. EMBS Micro and Nanotechnology in Medicine Conference, p.59, 2012
  24. Zhang, Y. Zhang, B. Keeley, A. Stark and T.H. Wang, “Fabricating and Applying Hierarchical Silica Nanomembrane with for Solid Phase DNA Extraction” The 6th IEEE International Conference on Nano/Molecular Medicine and Engineering (IEEE NANOMED 2012), 2012
  25. Keeley, Yi Zhang, Ye Zhang, A. Stark, T.H. Wang, “Quantum Dot FRET Linker Probes for Highly Sensitive DNA Methylation Detection”, Proc. IEEE 12th International Conference on Nanotechnology (IEEE NANO 2012), 7848, p.1-4, 2012
  26. Zhang and T.H. Wang, “Quantum Dot Electrophoretic Mobility Shift Assay and Its Application to the Measurement of Exonuclease Activity” Proc. IEEE 12th International Conference on Nanotechnology (IEEE NANO 2012), 7685, p.1-4, 2012
  27. Song, L. Zhang, M. Chen and T.H. Wang, “Single Quantum Dot Fluorescence Enhancement by Tunable Nanoporous Gold”, Proc. IEEE 12th International Conference on Nanotechnology (IEEE NANO 2012), 7877, p.1-4, 2012
  28. Zhang and T.H. Wang, “Droplet Immobilization, Splitting, Metering and Aliquoting with Surface Energy Traps Created Using SU8 Shadow Mask” Proc. 16th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (micro-TAS 2012), p. 73-75, 2012
  29. Zhang and T.H. Wang, “Surface Energy Trap Assisted Rapid Serial Dilution on Droplet Platform for Bacteria Antibiotics Susceptibility Test” Proc. 16th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (micro-TAS 2012), p. 467-469, 2012
  30. J. Liu, T.D. Rane, Y. Zhang, C. Beh, D.J. Shin, T.H. Wang, “An Integrated Platform for Single Molecule Free Solution Hydrodynamic Separation Using Yoctomoles of DNA and Picoliter Samples”, ASME 10th International Conference on Nanochannels, Microchannels and Minichannels (ICNMM 2012), ICNMM2012-73154 (p.1-6), 2012
  31. Zec, T.D. Rane, W.C. Chu and T.H. Wang, “Multiplexed Screening of a Large Library of Biological Samples through on-Demand Droplet Generation and Fusion”, ASME 2012 10th International Conference on Nanochannels, Microchannels and Minichannels (ICNMM 2012), ICNMM2012-73159 (p.1-6), 2012
  32. Song, Y. Zhang, and T.H. Wang, “Single Quantum Dot-Based Multiplexed Point Mutation Detection by Gap Ligase Chain Reaction”, Proc. 15th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (micro-TAS 2011), p.1779-1781, 2011
  33. Zhang, D.J. Shin and T.H. Wang, “Detecting Genetic Variations in A Droplet”, Proc. 15th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (micro-TAS 2011), p.1179-1181, 2011
  34. J. Liu and T.H. Wang, “ PCR-free, microfluidic single molecule analysis of circulating nucleic acids in lung cancer patient serum”, Proc. 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC ’11), p.8392-8395, 2011
  35. Zhang and T.H. Wang, “ An Active Gyroscopic Magnetic Micromixer for Rapid Fluid Mixing in Droplet Based Microfluidic Systems”, The 16th International Conference on Solid-State Sensors, Actuators and Microsystems(Transducers 2011), p.1769-1772, 2011
  36. Zhang, S.K. Park, S. Yang and T.H. Wang, “Fully Integrated Droplet Based Point-of-Care Platform for Molecular Detection from Crude Biosamples”, The 16th International Conference on Solid-State Sensors, Actuators and Microsystems(Transducers 2011), p.1927-1930, 2011
  37. H. Wang, V. Bailey and K. Liu, “Quantum Dots and Microfluidic Single Molecule Detection for Screening Genetic and Epigenetic Cancer Markers in Clinical Samples”, Proc. 2011 SPIE Defense, Security and Sensing Conference, Volume 8031, P. 80311W
  38. D. Rane, H. Zec, C.M. Puleo, A.P. Lee and T.H. Wang, “High-Throughput Single-Cell Pathogen Detection on a Droplet Microfluidic Platform”, Proc. 24th IEEE International Conference on Micro Electro Mechanical Systems (IEEE MEMS 2011), p.881-884, 2011
  39. Stark, Y. Zhang, V. Bailey, B. Keeley. T.H. Wang, “Increasing Throughput and Sensitivity of DNA Methylation Analysis through Functional Nanoparticles” The 6th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems (IEEE NEMS 2011), 1091-1094, 2011
  40. Y Zhang and T.H. Wang, “A Quantum Dot Based Electrophoretic Mobility Shift Assay for High Resolution Copy Number Variation Study”, The 6th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems (IEEE NEMS 2011), p.841-844, 2011
  41. Zhang, I.M. Shih, T.L. Wang and T.H. Wang, ” A Quantum Dot Based Nanoassay for Quantifying Gene Copy Number with Ultrahigh Resolution”, Proc. 14th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (micro-TAS 2010), p.1154-1156, 2010
  42. W. Beh, W. Zhou and T.H. Wang, “Oxygen Plasma-Free Microfluidic Device Sealing”, Proc. 14th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (micro-TAS 2010) p.1217-1219, 2010
  43. W. Beh, D. Kraitchman, H.Q. Mao, T.H. Wang, “High-throughput Monodisperse Alginate Gel Bead Formation using Microfluidic Pseudo-Check Valve”, Proc. 14th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (micro-TAS 2010) p.425-427, 2010
  44. Zhang and T.H. Wang, “An Automated All-in-one Microfluidic Device for Parallel Solid Phase DNA Extraction and Droplet-in-Oil PCR Analysis”, Proc. 23rd IEEE International Conference on Micro Electro Mechanical Systems (IEEE MEMS 2010), P.971-974, 2010
  45. Zhang and T.H. Wang, “Geomorphology-Assisted Manopulation of Magnet-Actuated Droplet for Solid Phase DNA Extraction and Droplet-in-Oil PCR”, Proc. 23rd IEEE International Conference on Micro Electro Mechanical Systems (IEEE MEMS 2010), p.1047-1050, 2010
  46. D. Rane, C.M. Puleo, H. Zec, Y. Zhang, A.P. Lee and T.H. Wamh, “Analyte Detection in Droplets: One Molecule at a Time”, Proc. 13th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (micro-TAS 2009), p.15-17, 2009
  47. M. Puleo, H.C. Zec, Y. Sung and T.H. Wang, “Micro-evaporator as Interconnects to Low-Volume Microfluidic Components”, Proc. 13th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (micro-TAS 2009), p.932-935, 2009
  48. J. Bailey, C.M. Puleo, Y.P. Ho, H.C. Yeh, T.H. Wang, “Quantum Dots in Molecular Detection of Diseases”, 31st Annual International Conference on the IEEE Engineering in Medicine and Biology Society ( IEEE EMBC 2009), p. 4089-4092, 2009
  49. Zhang, V. Bailey, C.M. Puleo, H. Easwaran, E. Griffiths, J.G. Herman, S.B. Baylin, T.H. Wang, “High Throughput DNA Methylation Analysis on a Droplet-in-Oil Polymerase Chain Reaction Array”, The 15th International Conference on Solid-State Sensors, Actuators and Microsystems(Transducers 2009), p.806-808, 2009
  50. Zhang, V. Bailey, C.M. Puleo, C. Chen and T.H. Wang, “Multiple gene Analysis within a Simple Droplet-in-Oil Microfluidic PCR Platform”, Proc. 12th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (micro-TAS 2008), p. 751-753 , 2008
  51. P. Ho, H.H. Chen, K. Leong and T.H. Wang “Quantitative Kinetic Analysis of DNA Nanocomplex Self-Assembly with Quantum Dots FRET in a Microfluidic Device”, Proc. 21st IEEE International Conference on Micro Electro Mechanical Systems (IEEE MEMS 2008), p. 30-33, 2008
  52. M. Puleo, H.C. Yeh and T.H. Wang “Single Molecule Detection in Truly, Nanoliter-Sized Volumes: Coupling Evaporation-Based, Microfluidic Concentration with Confocal Fluorescence Spectroscopy” Proc. 21st IEEE International Conference on Micro Electro Mechanical Systems (IEEE MEMS 2008), p.200-203, 2008
  53. Liu and T.H. Wang, “Quantitative Confocal Spectroscopy – Rectifying the Limitations of Single Molecule Detection”, Proc. 3rd Annual IEEE International Conferences on Nano/Micro Engineered and Molecular Systems (IEEE-NEMS 2008), p. 1189-1192, 2008
  54. C. Yeh. Y.P. Ho, C.M. Puleo and T.H. Wang,” Towards single-molecule diagnostics using microfluidic manipulation and quantum dot nanosensors, Proc. 5th International Conference on Nanochannels, Microchannels and Minichannels, (ICNMM 2007), p. 1133-1140, 2007
  55. P. Ho and T.H. Wang, “Multiplexed Detection of Anthrax Sequences with Quantum Dot Nanoprobes”, Proc. IEEE/NLM Life Science Systems and Application Workshop, p. 62-63, 2006
  56. Murray , K. Rebello, J. Crookston, J. Miragliotta and T.H. Wang, “High-degree Concentration of Bio-agents Using Electrokinetic Manipulations”, Proc. IEEE/NLM Life Science Systems and Application Workshop, p. 94-95, 2006
  57. P. Ho, M.C. Kung and T.H. Wang, ” Separation-free Detection of Low-abundant Biomolecules with Two-Color Colocalization of Quantum Dot Probes,” Proc. 9th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (micro-TAS 2005), p. 1330-1332, 2005
  58. C. Yeh, Y.P. Ho and T.H. Wang, “Quantum Dot-Mediated Separation-Free Assay for Point Mutation Detection ” Proc. NSTI- Bio-Nanotechnology Conference, 198-201, 2005
  59. C. Yeh, E. Simone, C.Y. Zhang and T.H. Wang, “Single Bio-Molecule Detection with Quantum-dots in Flow-rate Controlled Microchannel”, Proc. 17h IEEE Annual Workshop of Micro Electro Mechanical Systems (IEEE MEMS 2004), p 371-374, 2004
  60. Y. Chao, C.Y. Zhang and T.H. Wang,” Measurement of in-situ Flow Velocity Using Single-Molecule Detection for the Application of Biomolecule Quantification”, Proc. Hilton Head 2004 Solid-State Sensor, Actuator, and Microsystems Workshop (Hilton Head 2004), p. 176-179, 2004
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  64. K. Wong, T.H. Wang and C.M. Ho, “Optical Fiber Tip Fabricated by Surface Tension Controlled Etching”, Proc. Hilton Head 2002: Solid-State Sensor, Actuator, and Microsystems Workshop (Hilton Head 2002), p. 94-97, 2002
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