Mechanical Engineering 2018 Spring Seminar Series: Class 530.804
“3D-Printed Shape-changing RV-PA Conduits for Pediatrics”
Presented by Dr. Galip Ozan Erol
Department of Mechanical Engineering, Johns Hopkins University
Each year, millions of infants are born in the US and it is estimated that 20% of the newborn deaths are due to the birth defects with congenital heart defects (CHDs) being the most common type (about 40,00 births every year). Right ventricle-to-Pulmonary artery (RV-PA) conduits are frequently used to treat these complex defects in pediatrics from birth. Currently used implants to treat these defects cannot adapt to the growth of the infants and they eventually require multiple (at least 3) open-heart replacement surgeries. Hence, these inevitable surgeries result in decrease in quality-of-life and increased medical burden as the infant grows and reaches adulthood. To address this issue, we have developed self-adaptable RV-PA conduits that can change their shape in response to the physiological changes such that fewer surgeries are required to maintain healthy pulmonary circulation during growth. In this talk, I will discuss our current progress on the development of 3D-printed self-adaptable RV-PA conduit designs and their numerical simulations under various mechanical loads mimicking infant growth. I will also present our experimental efforts to 3D print FDA-approved materials for cardiovascular devices and in-vitro functionality tests to demonstrate that the implants can undergo shape-change under pulsatile flow changes observed during growth. We believe that our self-adaptive conduits can contribute to minimizing the number of surgical operations during the growth of infants with CHDs.
Dr. Galip Ozan Erol is a postdoctoral fellow in the Department of Mechanical Engineering, and Chemical and Biomolecular Engineering, focusing on pediatric cardiovascular implants under the guidance of Profs. Sung-Hoon Kang, David Gracias, Lewis Romer and Narutoshi Hibino. Ozan graduated from the Middle East Technical University in 2009 with his Bachelor of Science Degree in Mechanical Engineering with a Minor in Mechatronics. He completed his Master’s Degree at Washington State University in 2010 with a focus on smart materials and actuators. In 2016, he received his PhD Degree from the University of Delaware (UD) where his research focused on the development of a multi-length scale design framework for advanced woven fabrics. During his PhD, he authored 9 journal publications in various journals, and received University of Delaware Dissertation Fellowship and Graduate Student Achievement awards. He is also a professional member of ASME and SAMPE.