Department of Mechanical Engineering Fall Seminar Series
Functional Biomaterials for Regenerative Medicine
Presented by Professor Treena Livingston Arinzeh
Department of Biomedical Engineering, New Jersey Institute of Technology
Stem cells are a promising cell source in the tissue engineering and regenerative medicine fields. Intense studies have been focused at the cell and molecular biology levels on understanding the relationship between stem cell growth and differentiation in an effort to control these processes. Recent discoveries have shown that the microenvironment can influence stem cell self-renewal and differentiation, which has had a tremendous impact on identifying potential strategies for using these cells effectively in the body. This presentation will describe studies examining the influence of biomaterials on stem cell behavior with an emphasis on identifying biomaterial designs and chemistries that impart appropriate cues to stem cells to affect their behavior both in vitro and in vivo. Recent results using biomimetic materials, specifically piezoelectric polymers, that provide electromechanical cues to stem cells and novel glycosaminoglycan mimetics that prolong the bioactivity of growth factors and induce differentiation will be discussed.
Treena Livingston Arinzeh, PhD is a Professor of Biomedical Engineering at the New Jersey Institute of Technology (NJIT). Dr. Arinzeh received her B.S. from Rutgers University in Mechanical Engineering, her M.S.E. in Biomedical Engineering from Johns Hopkins University, and her Ph.D. in Bioengineering from the University of Pennsylvania. She worked for several years as a project manager at a stem cell technology company, Osiris Therapeutics, Inc. Dr. Arinzeh joined the faculty of NJIT as one of the founding faculty members of the department of Biomedical Engineering and served as interim chairperson and graduate director. Her most notable or cited work to date has been in the use of allogeneic mesenchymal stem cells (MSCs) with bioactive ceramics to induce bone formation in a large bone defect without the use of immunosuppressive therapy. This study served the basis for FDA approval to pursue clinical trials using allogeneic MSCs for various applications. Dr. Arinzeh has been recognized with numerous awards, including the National Science Foundation (NSF) CAREER Award and the Presidential Early Career Award for Scientists and Engineers (PECASE). She was nominated by the Governor of Connecticut to the Connecticut Stem Cell Research Advisory Committee. She is a fellow of the American Institute for Medical and Biological Engineering (AIMBE) and the Biomedical Engineering Society (BMES). She recently served as the chairperson for the National Institutes of Health (NIH) Musculoskeletal Tissue Engineering (MTE) Study Section. She is currently a co-PI of the NSF Science and Technology Center on Engineering Mechanobiology, which is a multi-institutional center with the University of Pennsylvania and Washington University in Saint Louis. She has also made a significant impact in the recruitment and mentoring of underrepresented minorities and women in biomedical engineering and other STEM fields.